SCHEMBL4038368

SCHEMBL4038368

O=C(NC1CCCCC1)C(C1CCCCC1)C1(c2ccc(-c3ccccc3)s2)Nc2ccccc2N1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHEK1 O14757 1/20 0.41
ESR1 P03372 1/20 0.41
ESRRG P62508 1/20 0.41
ESR2 Q92731 1/20 0.41
PTPN1 P18031 1/20 0.41
PTPN11 Q06124 1/20 0.41
TSHR P16473 2/20 0.39
MEN1 O00255 4/20 0.39
KMT2A Q03164 4/20 0.39
SMN1; SMN2 Q16637 3/20 0.39
ALDH1A1 P00352 2/20 0.39
LMNA P02545 1/20 0.39
NPSR1 Q6W5P4 1/20 0.39
FAAH O00519 1/20 0.38
S1PR1 P21453 1/20 0.38
EPHX1 P07099 2/20 0.37
CCNA2 P20248 1/20 0.37
CDK2 P24941 1/20 0.37
KDR P35968 1/20 0.37
PLK1 P53350 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4037433 0.85 KMT2A (0.41) TSHRMEN1KMT2ASMN1; SMN2ALDH1A1
SCHEMBL4040574 0.85 KMT2A (0.41) TSHRMEN1KMT2ASMN1; SMN2ALDH1A1
SCHEMBL4042940 0.82 TSHR (0.45) TSHRMEN1KMT2ASMN1; SMN2ALDH1A1
SCHEMBL4036629 0.80 NPC1 (0.49) TSHRMEN1KMT2ASMN1; SMN2ALDH1A1
SCHEMBL4036420 0.79 OPRM1 (0.41) MEN1KMT2ASMN1; SMN2ALDH1A1FAAH
SCHEMBL4037892 0.78 RAB9A (0.41) CHEK1TSHRMEN1KMT2ASMN1; SMN2
SCHEMBL4039455 0.77 KMT2A (0.48) TSHRMEN1KMT2ASMN1; SMN2ALDH1A1
SCHEMBL4043049 0.76 SMN1; SMN2 (0.46) TSHRMEN1KMT2ASMN1; SMN2ALDH1A1
SCHEMBL4044888 0.76 KMT2A (0.45) TSHRMEN1KMT2ASMN1; SMN2ALDH1A1
SCHEMBL4038973 0.76 NPC1 (0.46) TSHRMEN1KMT2ASMN1; SMN2ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2038259-A1 BENZIMIDAZOLE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, THEIR USE AS FXR AGONISTS AND PHARMACEUTICAL PREPARATIONS CONTAINING THE SAME F.HOFFMANN-LA ROCHE AG (CH) 2009-03-25 EP claimed
WO-2008000643-A1 BENZIMIDAZOLE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, THEIR USE AS FXR AGONISTS AND PHARMACEUTICAL PREPARATIONS CONTAINING THE SAME F. HOFFMANN-LA ROCHE AG (CH) 2008-01-03 WO claimed
EP-3043865-A1 METHODS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF HEPATITIS B VIRUS INFECTION Institut National de la Santé et de la Recherche Médicale (INSERM) (FR) 2016-07-20 EP disclosed
WO-2015036442-A1 METHODS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF HEPATITIS B VIRUS INFECTION INSERM (Institut National de la Santé et de la Recherche Médicale) (FR) 2015-03-19 WO disclosed
EP-2038259-A1 BENZIMIDAZOLE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, THEIR USE AS FXR AGONISTS AND PHARMACEUTICAL PREPARATIONS CONTAINING THE SAME F.HOFFMANN-LA ROCHE AG (CH) 2009-03-25 EP disclosed
WO-2008000643-A1 BENZIMIDAZOLE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, THEIR USE AS FXR AGONISTS AND PHARMACEUTICAL PREPARATIONS CONTAINING THE SAME F. HOFFMANN-LA ROCHE AG (CH) 2008-01-03 WO disclosed