Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 12/20 | 0.50 |
| ▸ | CTSS | P25774 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CCR1 | P32246 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 2/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CTSV | O60911 | 2/20 | 0.34 |
| ▸ | CTSL | P07711 | 2/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4043807 | 0.92 | CTSK (0.41) | CTSKCTSSCCR1CTSVCTSL | |
| SCHEMBL4042967 | 0.92 | CTSK (0.52) | CTSKCTSSPOLBCA2CTSL | |
| SCHEMBL4045094 | 0.91 | CTSK (0.51) | CTSKCTSSPOLBCCR1CA2 | |
| SCHEMBL4039563 | 0.91 | CTSK (0.54) | CTSKCTSSCCR1CA2CA1 | |
| SCHEMBL4038667 | 0.90 | CTSK (0.54) | CTSKCTSSCCR1CA2CA1 | |
| SCHEMBL4045969 | 0.89 | CTSK (0.56) | CTSKCTSSCCR1CA2CA1 | |
| SCHEMBL4042980 | 0.89 | CTSK (0.53) | CTSKCTSSCCR1CA2CA1 | |
| SCHEMBL4039332 | 0.89 | CTSK (0.53) | CTSKCTSSPOLBCCR1CA2 | |
| SCHEMBL4040927 | 0.89 | CTSK (0.51) | CTSKCTSSPOLBCCR1CTSV | |
| SCHEMBL4040650 | 0.88 | CTSK (0.65) | CTSKCTSSCCR1CA2CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546150-B1 | PYRROLE DERIVATIVES AS INHIBITORS OF CYTEINE PROTEASES | AMURA THERAPEUTICS LTD (GB) | 2009-03-04 | — | — | EP | claimed |
| EP-1678157-A4 | HETEROCYCLIC COMPOUNDS AND METHODS OF MAKING AND USING THEREOF | REDDY US THERAPEUTICS INC (US) | 2009-03-18 | — | — | EP | disclosed |
| EP-1678157-A2 | HETEROCYCLIC COMPOUNDS AND METHODS OF MAKING AND USING THEREOF | Reddy US Therapeutics, Inc. (US) | 2006-07-12 | — | — | EP | disclosed |
| EP-1546150-A1 | BIOLOGICALLY ACTIVE COMPOUNDS | Amura Therapeutics Limited (GB) | 2005-06-29 | — | — | EP | disclosed |
| WO-2005042712-A2 | HETEROCYCLIC COMPOUNDS AND METHODS OF MAKING AND USING THEREOF | REDDY US THERAPEUTICS, INC. (US) | 2005-05-12 | — | — | WO | disclosed |
| WO-2004007501-A1 | BIOLOGICALLY ACTIVE COMPOUNDS | AMURA THERAPEUTICS LIMITED (GB) | 2004-01-22 | — | — | WO | disclosed |