Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.41 |
| ▸ | APBA1 | Q02410 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.38 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4035291 | 0.84 | EGFR (0.42) | TSHRALDH1A1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL4040611 | 0.82 | NR1H4 (0.39) | TSHRALDH1A1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL4041338 | 0.81 | SMN1; SMN2 (0.41) | TSHRALDH1A1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL4036629 | 0.80 | NPC1 (0.49) | TSHRALDH1A1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL4037383 | 0.80 | KMT2A (0.41) | TSHRALDH1A1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL4037171 | 0.80 | NPC1 (0.47) | TSHRRAB9ANPC1SMN1; SMN2KMT2A | |
| SCHEMBL4042729 | 0.80 | HPGD (0.44) | TSHRALDH1A1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL4042940 | 0.79 | TSHR (0.45) | TSHRALDH1A1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL4039886 | 0.79 | POLB (0.47) | TSHRALDH1A1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL4044509 | 0.79 | TSHR (0.44) | TSHRRAB9ANPC1SMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2038259-A1 | BENZIMIDAZOLE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, THEIR USE AS FXR AGONISTS AND PHARMACEUTICAL PREPARATIONS CONTAINING THE SAME | F.HOFFMANN-LA ROCHE AG (CH) | 2009-03-25 | — | — | EP | disclosed |
| WO-2008000643-A1 | BENZIMIDAZOLE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, THEIR USE AS FXR AGONISTS AND PHARMACEUTICAL PREPARATIONS CONTAINING THE SAME | F. HOFFMANN-LA ROCHE AG (CH) | 2008-01-03 | — | — | WO | disclosed |