Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.36 |
| ▸ | MLYCD | O95822 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4040007 | 0.89 | TSHR (0.47) | TSHRKMT2AMEN1SMN1; SMN2HTT | |
| SCHEMBL4039886 | 0.82 | POLB (0.47) | TSHRKMT2AMEN1SMN1; SMN2NPC1 | |
| SCHEMBL4036736 | 0.82 | LMNA (0.46) | TSHRKMT2AMEN1SMN1; SMN2HTT | |
| SCHEMBL4036629 | 0.80 | NPC1 (0.49) | TSHRKMT2AMEN1SMN1; SMN2HTT | |
| SCHEMBL4039913 | 0.79 | TSHR (0.46) | TSHRKMT2AMEN1SMN1; SMN2HTT | |
| SCHEMBL4038652 | 0.79 | TSHR (0.43) | TSHRKMT2AMEN1SMN1; SMN2HTT | |
| SCHEMBL4037171 | 0.78 | NPC1 (0.47) | TSHRKMT2AMEN1SMN1; SMN2LMNA | |
| SCHEMBL4042729 | 0.78 | HPGD (0.44) | TSHRKMT2AMEN1SMN1; SMN2HTT | |
| SCHEMBL4042940 | 0.78 | TSHR (0.45) | TSHRKMT2AMEN1SMN1; SMN2HTT | |
| SCHEMBL4044482 | 0.77 | LMNA (0.44) | TSHRKMT2AMEN1SMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2038259-A1 | BENZIMIDAZOLE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, THEIR USE AS FXR AGONISTS AND PHARMACEUTICAL PREPARATIONS CONTAINING THE SAME | F.HOFFMANN-LA ROCHE AG (CH) | 2009-03-25 | — | — | EP | disclosed |
| WO-2008000643-A1 | BENZIMIDAZOLE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, THEIR USE AS FXR AGONISTS AND PHARMACEUTICAL PREPARATIONS CONTAINING THE SAME | F. HOFFMANN-LA ROCHE AG (CH) | 2008-01-03 | — | — | WO | disclosed |