Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | GAA | P10253 | 4/20 | 0.40 |
| ▸ | ESR1 | P03372 | 4/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.35 |
| ▸ | PRKDC | P78527 | 1/20 | 0.34 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | CASP7 | P55210 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.32 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4046001 | 1.00 | KDM4E (0.40) | KDM4EALDH1A1GAAESR1L3MBTL1 | |
| SCHEMBL6333988 | 0.90 | KDM4E (0.39) | KDM4EALDH1A1GAAESR1L3MBTL1 | |
| SCHEMBL4037837 | 0.88 | GAA (0.39) | KDM4EALDH1A1GAAESR1L3MBTL1 | |
| SCHEMBL4037833 | 0.88 | GAA (0.39) | KDM4EALDH1A1GAAESR1L3MBTL1 | |
| SCHEMBL4043399 | 0.87 | HRH4 (0.38) | KDM4EALDH1A1MAPK1KMT2ASMN1; SMN2 | |
| SCHEMBL4037785 | 0.87 | HRH4 (0.38) | KDM4EALDH1A1MAPK1KMT2ASMN1; SMN2 | |
| SCHEMBL4035860 | 0.87 | ALOX5 (0.39) | KDM4EALDH1A1GAAESR1L3MBTL1 | |
| SCHEMBL4035859 | 0.87 | ALOX5 (0.39) | KDM4EALDH1A1GAAESR1L3MBTL1 | |
| SCHEMBL4036046 | 0.75 | HRH4 (0.39) | KDM4EALDH1A1NOTUMTSHRMAPK1 | |
| SCHEMBL4036049 | 0.75 | HRH4 (0.39) | KDM4EALDH1A1NOTUMTSHRMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1284977-B1 | THIENODIBENZOAZULENE COMPOUNDS AS TUMOR NECROSIS FACTOR INHIBITORS | GLAXOSMITHKLINE ZAGREB (HR) | 2009-06-24 | — | — | EP | claimed |
| EP-1284977-B1 | THIENODIBENZOAZULENE COMPOUNDS AS TUMOR NECROSIS FACTOR INHIBITORS | GLAXOSMITHKLINE ZAGREB (HR) | 2009-06-24 | — | — | EP | disclosed |