Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HRH2 | P25021 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.35 |
| ▸ | TUBB | P07437 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4037785 | 1.00 | HRH4 (0.38) | HRH4MAPK1HRH2MAPTKDM4E | |
| SCHEMBL6333988 | 0.90 | KDM4E (0.39) | MAPK1MAPTKDM4EALDH1A1CYP1A2 | |
| SCHEMBL4036049 | 0.88 | HRH4 (0.39) | HRH4MAPK1HRH2MAPTKDM4E | |
| SCHEMBL4036046 | 0.88 | HRH4 (0.39) | HRH4MAPK1HRH2MAPTKDM4E | |
| SCHEMBL4046001 | 0.87 | KDM4E (0.40) | MAPK1MAPTKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL4038718 | 0.87 | KDM4E (0.40) | MAPK1MAPTKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL4037837 | 0.75 | GAA (0.39) | MAPTKDM4EALDH1A1LMNAKMT2A | |
| SCHEMBL4037833 | 0.75 | GAA (0.39) | MAPTKDM4EALDH1A1LMNAKMT2A | |
| SCHEMBL6342108 | 0.75 | CA12 (0.39) | MAPTKDM4EALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL4035859 | 0.73 | ALOX5 (0.39) | HRH4MAPK1HRH2MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1284977-B1 | THIENODIBENZOAZULENE COMPOUNDS AS TUMOR NECROSIS FACTOR INHIBITORS | GLAXOSMITHKLINE ZAGREB (HR) | 2009-06-24 | — | — | EP | claimed |