SCHEMBL4038847

SCHEMBL4038847

Cc1ccncc1-c1c(C#N)c(C(N)=O)c2n1CCN(C(=O)OC(C)(C)C)C2

nearest known ligand 0.39

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
GPR119 Q8TDV5 11/20 0.39
NR1H2 P55055 2/20 0.36
CSNK1E P49674 3/20 0.35
JAK2 O60674 2/20 0.35
JAK1 P23458 2/20 0.35
SQOR Q9Y6N5 1/20 0.35
CSNK1D P48730 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4042990 0.91 GPR119 (0.42) GPR119NR1H2SQOR
SCHEMBL4043737 0.86 NR1H2 (0.39) GPR119NR1H2CSNK1ECSNK1D
SCHEMBL4039078 0.86 CSNK1E (0.46) GPR119NR1H2CSNK1EJAK2JAK1
SCHEMBL4039352 0.84 SQOR (0.41) GPR119NR1H2CSNK1EJAK2JAK1
SCHEMBL4038604 0.81 CSNK1E (0.46) NR1H2CSNK1ECSNK1D
SCHEMBL4038225 0.79 GPR119 (0.46) GPR119NR1H2
SCHEMBL4039386 0.78 GPR119 (0.45) GPR119NR1H2
SCHEMBL4037481 0.77 GPR119 (0.40) GPR119NR1H2
SCHEMBL4041480 0.76 GBA1 (0.49) GPR119NR1H2CSNK1ECSNK1D
SCHEMBL4045206 0.75 CSNK1E (0.47) GPR119NR1H2CSNK1ECSNK1D

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 56 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3950911-A1 AUTOMATIC DISHWASHING METHOD The Procter & Gamble Company (US) 2022-02-09 EP claimed
EP-4488351-A1 COMPOSITIONS CONTAINING A PORPHYRIN BINDING PROTEIN The Procter & Gamble Company (US) 2025-01-08 EP disclosed
EP-4481027-A1 CLEANING COMPOSITIONS CONTAINING ENZYMES The Procter & Gamble Company (US) 2024-12-25 EP disclosed
EP-3485010-B1 BACILLUS CIBI DNASE VARIANTS AND USES THEREOF PROCTER & GAMBLE (US) 2024-11-06 EP disclosed
EP-4410941-A1 DETERGENT COMPOSITIONS CONTAINING ENZYMES The Procter & Gamble Company (US) 2024-08-07 EP disclosed
EP-4276179-A2 ALPHA-AMYLASE VARIANTS Novozymes A/S (DK) 2023-11-15 EP disclosed
EP-4273210-A1 DETERGENT COMPOSITIONS CONTAINING ENZYMES The Procter & Gamble Company (US) 2023-11-08 EP disclosed
EP-3121270-B1 CLEANING COMPOSITIONS COMPRISING AMYLASE VARIANTS REFERENCE TO A SEQUENCE LISTING PROCTER & GAMBLE (US) 2023-11-01 EP disclosed
EP-3357994-B1 CLEANING COMPOSITIONS COMPRISING AMYLASE VARIANTS PROCTER & GAMBLE (US) 2023-11-01 EP disclosed
US-20230340378-A1 DETERGENT COMPOSITIONS CONTAINING ENZYMES THE PROCTER & GAMBLE COMPANY 2023-10-26 US disclosed
EP-2540824-A1 Cleaning compositions comprising amylase variants reference to a sequence listing The Procter & Gamble Company (US) 2013-01-02 EP disclosed
EP-1828364-B1 A COMPOSITION WITH A METAL-COMPLEXING DYE AND SURFACTANT PROCTER & GAMBLE (US) 2009-04-29 EP disclosed
EP-1436291-B1 INDOLIZINES AS KINASE PROTEIN INHIBITORS AVENTIS PHARMA SA (FR) 2009-01-14 EP disclosed
EP-2010504-A1 QUINAZOLIN-4-ONE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AstraZeneca AB (SE) 2009-01-07 EP disclosed
WO-2007119055-A1 QUINAZOLIN-4-ONE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM ASTRAZENECA AB (SE) 2007-10-25 WO disclosed
US-20070238734-A1 JNK INHIBITORS SANOLI-AVENTIS (FR) 2007-10-11 US disclosed
US-7148215-B2 Prodrugs as antihistamines or anticarcinogenic agents AVENTIS PHARMA S.A. (FR) 2006-12-12 US disclosed
US-20050009831-A1 Pyrrolo[1,2-a]pyrazine-8-carboxamides are JNK inhibitors, useful as anticarcinogenic agents AVENTIS PHARMA S.A, (FR) 2005-01-13 US disclosed
EP-1436291-A2 INDOLIZINES AS KINASE PROTEIN INHIBITORS Aventis Pharma S.A. (FR) 2004-07-14 EP disclosed
WO-2003024967-A2 INDOLIZINES AS KINASE PROTEIN INHIBITORS AVENTIS PHARMA S.A. (FR) 2003-03-27 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070238734-A1 JNK INHIBITORS MAP3K7, MAPKAPK2, MAPK7 GPR119 770/4885NR1H2 398/4885CSNK1E 136/4885
US-20050009831-A1 Pyrrolo[1,2-a]pyrazine-8-carboxamides are JNK inhibitors, useful as anticarcinogenic agents CNKSR1, ROS1, NRAS GPR119 631/4885NR1H2 322/4885CSNK1E 243/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.