Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2B | P41595 | 2/20 | 0.50 |
| ▸ | NR3C2 | P08235 | 12/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.35 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.35 |
| ▸ | PGR | P06401 | 1/20 | 0.35 |
| ▸ | AR | P10275 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2253808 | 1.00 | HTR2B (0.50) | HTR2BNR3C2CYP3A4CYP2C9CYP2D6 | |
| SCHEMBL2253812 | 1.00 | HTR2B (0.50) | HTR2BNR3C2CYP3A4CYP2C9CYP2D6 | |
| SCHEMBL2251060 | 0.91 | NR3C2 (0.58) | HTR2BNR3C2CYP3A4CYP2C9CYP2D6 | |
| SCHEMBL2251054 | 0.91 | NR3C2 (0.58) | HTR2BNR3C2CYP3A4CYP2C9CYP2D6 | |
| SCHEMBL3090362 | 0.91 | NR3C2 (0.58) | HTR2BNR3C2CYP3A4CYP2C9CYP2D6 | |
| SCHEMBL3664130 | 0.79 | NR3C2 (0.46) | HTR2BNR3C2CYP3A4CYP2C9CYP2D6 | |
| SCHEMBL2251150 | 0.79 | NR3C2 (0.46) | HTR2BNR3C2CYP3A4CYP2C9CYP2D6 | |
| SCHEMBL2251145 | 0.79 | NR3C2 (0.46) | HTR2BNR3C2CYP3A4CYP2C9CYP2D6 | |
| SCHEMBL4045716 | 0.78 | CYP11B2 (0.46) | — | |
| SCHEMBL13802528 | 0.76 | HTR2B (0.41) | HTR2BNR3C2MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090149445-A1 | TRICYCLIC STEROID HORMONE NUCLEAR RECEPTOR MODULATORS | COGHLAN MICHAEL JOSEPH | 2009-06-11 | — | — | US | disclosed |
| EP-1519915-B1 | TRICYCLIC STEROID HORMONE NUCLEAR RECEPTOR MODULATORS | LILLY CO ELI (US) | 2009-05-27 | — | — | EP | disclosed |
| US-7411072-B2 | Tricyclic steroid hormone nuclear receptor modulators | ELI LILLY AND COMPANY (US) | 2008-08-12 | — | — | US | disclosed |
| US-20060063759-A1 | Tricyclic steroid hormone nuclear receptor modulators | ELI LILLY AND COMPANY | 2006-03-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090149445-A1 | TRICYCLIC STEROID HORMONE NUCLEAR RECEPTOR MODULATORS | NR5A1, NR3C2, NR3C1 | HTR2B 962/4885NR3C2 2/4885CYP3A4 385/4885 |
| US-20060063759-A1 | Tricyclic steroid hormone nuclear receptor modulators | NR5A1, NR3C2, NR3C1 | HTR2B 891/4885NR3C2 2/4885CYP3A4 381/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.