Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 7/20 | 0.63 |
| ▸ | MEN1 | O00255 | 6/20 | 0.63 |
| ▸ | MAPT | P10636 | 6/20 | 0.63 |
| ▸ | LMNA | P02545 | 1/20 | 0.63 |
| ▸ | POLB | P06746 | 1/20 | 0.63 |
| ▸ | RAB9A | P51151 | 3/20 | 0.60 |
| ▸ | NPC1 | O15118 | 1/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.60 |
| ▸ | KCNQ3 | O43525 | 2/20 | 0.59 |
| ▸ | KCNQ2 | O43526 | 2/20 | 0.59 |
| ▸ | KCNE1 | P15382 | 2/20 | 0.59 |
| ▸ | KCNQ1 | P51787 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16104986 | 0.85 | MEN1 (0.65) | KMT2AMEN1MAPTLMNAPOLB | |
| SCHEMBL3134896 | 0.83 | KCNQ3 (0.78) | KMT2AMEN1MAPTLMNAPOLB | |
| SCHEMBL16097836 | 0.82 | KCNQ3 (0.49) | KMT2AMEN1MAPTPOLBRAB9A | |
| SCHEMBL1456159 | 0.81 | MEN1 (0.63) | KMT2AMEN1MAPTLMNAPOLB | |
| SCHEMBL9237760 | 0.80 | MEN1 (0.72) | KMT2AMEN1MAPTLMNAPOLB | |
| SCHEMBL27942800 | 0.80 | KMT2A (0.72) | KMT2AMEN1MAPTLMNAPOLB | |
| SCHEMBL15176813 | 0.80 | MEN1 (0.68) | KMT2AMEN1MAPTLMNAPOLB | |
| SCHEMBL401850 | 0.79 | KCNQ3 (0.64) | KMT2AMEN1MAPTLMNARAB9A | |
| SCHEMBL2302662 | 0.79 | KCNQ3 (0.64) | KMT2AMEN1MAPTLMNARAB9A | |
| SCHEMBL404305 | 0.78 | MAPT (0.60) | KMT2AMEN1MAPTLMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1957461-B1 | BISAMIDE INHIBITORS OF HEDGEHOG SIGNALING | GENENTECH INC (US) | 2016-11-02 | — | — | EP | disclosed |
| US-8101610-B2 | Blocking signals; anticancer agents | GENENTECH, INC. (US) | 2012-01-24 | — | — | US | disclosed |
| US-20080269215-A1 | Bisamide Inhibitors of Hedgehog Signaling | GENENTECH INC. (US) | 2008-10-30 | — | — | US | disclosed |
| EP-1957461-A1 | BISAMIDE INHIBITORS OF HEDGEHOG SIGNALING | Genentech, Inc. (US) | 2008-08-20 | — | — | EP | disclosed |
| WO-2007059157-A1 | BISAMIDE INHIBITORS OF HEDGEHOG SIGNALING | GENENTECH, INC. (US) | 2007-05-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080269215-A1 | Bisamide Inhibitors of Hedgehog Signaling | SHH, GLI1, SMO | KMT2A 507/4885MEN1 272/4885MAPT 2726/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.