Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNQ3 | O43525 | 8/20 | 0.78 |
| ▸ | KCNQ2 | O43526 | 8/20 | 0.78 |
| ▸ | KCNE1 | P15382 | 6/20 | 0.78 |
| ▸ | KCNQ1 | P51787 | 6/20 | 0.78 |
| ▸ | RAB9A | P51151 | 5/20 | 0.69 |
| ▸ | MAPT | P10636 | 3/20 | 0.69 |
| ▸ | NPC1 | O15118 | 3/20 | 0.69 |
| ▸ | MEN1 | O00255 | 3/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.69 |
| ▸ | PKM | P14618 | 1/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.67 |
| ▸ | LMNA | P02545 | 2/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.60 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.60 |
| ▸ | BACE1 | P56817 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5214441 | 0.88 | KCNQ3 (1.00) | KCNQ3KCNQ2KCNE1KCNQ1RAB9A | |
| SCHEMBL2302662 | 0.87 | KCNQ3 (0.64) | KCNQ3KCNQ2KCNE1KCNQ1RAB9A | |
| SCHEMBL2300783 | 0.87 | MAPT (0.63) | KCNQ3KCNQ2KCNE1KCNQ1RAB9A | |
| SCHEMBL401850 | 0.87 | KCNQ3 (0.64) | KCNQ3KCNQ2KCNE1KCNQ1RAB9A | |
| SCHEMBL5215207 | 0.85 | KCNQ3 (0.81) | KCNQ3KCNQ2KCNE1KCNQ1RAB9A | |
| SCHEMBL4257363 | 0.85 | NPC1 (0.65) | KCNQ3KCNQ2KCNE1KCNQ1RAB9A | |
| SCHEMBL403003 | 0.84 | KCNQ3 (0.68) | KCNQ3KCNQ2KCNE1KCNQ1RAB9A | |
| SCHEMBL1986996 | 0.83 | KCNQ3 (0.82) | KCNQ3KCNQ2KCNE1KCNQ1RAB9A | |
| SCHEMBL403892 | 0.83 | KMT2A (0.63) | KCNQ3KCNQ2KCNE1KCNQ1RAB9A | |
| SCHEMBL4969173 | 0.83 | KCNQ3 (0.63) | KCNQ3KCNQ2KCNE1KCNQ1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120238750-A1 | AROMATIC COMPOUND | OTSUKA PHARMACEUTICAL CO., LTD. | 2012-09-20 | — | — | US | disclosed |
| US-8236826-B2 | Diarylether derivatives as antitumor agents | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2012-08-07 | — | — | US | disclosed |
| US-8188277-B2 | Aromatic compounds for suppressing the generation of collagen | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2012-05-29 | — | — | US | disclosed |
| US-20100004438-A1 | DIARYLETHER DERIVATIVES AS ANTITUMOR AGENTS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2010-01-07 | — | — | US | disclosed |
| EP-1957073-A2 | MEDICINAL DRUG | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2008-08-20 | — | — | EP | disclosed |
| US-20070270422-A1 | Aromatic Compounds | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2007-11-22 | — | — | US | disclosed |
| WO-2007066784-A2 | DIARYLETHER DERIVATIVES AS ANTITUMOR AGENTS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2007-06-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120238750-A1 | AROMATIC COMPOUND | CBR1, CBR3, CYP1A1 | KCNQ3 1570/4885KCNQ2 1451/4885KCNE1 453/4885 |
| US-20100004438-A1 | DIARYLETHER DERIVATIVES AS ANTITUMOR AGENTS | ROS1, CBR1, CBR3 | KCNQ3 4035/4885KCNQ2 3926/4885KCNE1 2330/4885 |
| US-20070270422-A1 | Aromatic Compounds | COL1A1, COL2A1, COL14A1 | KCNQ3 3700/4885KCNQ2 3623/4885KCNE1 2527/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.