Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNQ3 | O43525 | 11/20 | 0.64 |
| ▸ | KCNQ2 | O43526 | 11/20 | 0.64 |
| ▸ | KCNE1 | P15382 | 8/20 | 0.64 |
| ▸ | KCNQ1 | P51787 | 8/20 | 0.64 |
| ▸ | RAB9A | P51151 | 3/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.62 |
| ▸ | MAPT | P10636 | 5/20 | 0.61 |
| ▸ | MEN1 | O00255 | 4/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | BACE1 | P56817 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3134896 | 0.87 | KCNQ3 (0.78) | KCNQ3KCNQ2KCNE1KCNQ1RAB9A | |
| SCHEMBL2302662 | 0.83 | KCNQ3 (0.64) | KCNQ3KCNQ2KCNE1KCNQ1RAB9A | |
| SCHEMBL5215207 | 0.82 | KCNQ3 (0.81) | KCNQ3KCNQ2KCNE1KCNQ1RAB9A | |
| SCHEMBL11574336 | 0.81 | NPC1 (0.59) | KCNQ3KCNQ2KCNE1KCNQ1RAB9A | |
| SCHEMBL10890300 | 0.81 | MEN1 (0.66) | RAB9ASMN1; SMN2MAPTMEN1KMT2A | |
| SCHEMBL2300783 | 0.81 | MAPT (0.63) | KCNQ3KCNQ2KCNE1KCNQ1RAB9A | |
| SCHEMBL5897079 | 0.81 | LMNA (0.54) | KCNQ3KCNQ2KCNE1KCNQ1RAB9A | |
| SCHEMBL403003 | 0.80 | KCNQ3 (0.68) | KCNQ3KCNQ2KCNE1KCNQ1RAB9A | |
| SCHEMBL1986996 | 0.79 | KCNQ3 (0.82) | KCNQ3KCNQ2KCNE1KCNQ1RAB9A | |
| SCHEMBL4969173 | 0.79 | KCNQ3 (0.63) | KCNQ3KCNQ2KCNE1KCNQ1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1957461-B1 | BISAMIDE INHIBITORS OF HEDGEHOG SIGNALING | GENENTECH INC (US) | 2016-11-02 | — | — | EP | disclosed |
| US-8101610-B2 | Blocking signals; anticancer agents | GENENTECH, INC. (US) | 2012-01-24 | — | — | US | disclosed |
| US-20080269215-A1 | Bisamide Inhibitors of Hedgehog Signaling | GENENTECH INC. (US) | 2008-10-30 | — | — | US | disclosed |
| EP-1957461-A1 | BISAMIDE INHIBITORS OF HEDGEHOG SIGNALING | Genentech, Inc. (US) | 2008-08-20 | — | — | EP | disclosed |
| WO-2007059157-A1 | BISAMIDE INHIBITORS OF HEDGEHOG SIGNALING | GENENTECH, INC. (US) | 2007-05-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080269215-A1 | Bisamide Inhibitors of Hedgehog Signaling | SHH, GLI1, SMO | KCNQ3 3763/4885KCNQ2 3497/4885KCNE1 1755/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.