Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Azelaic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.60 |
| ▸ | CA12 | O43570 | 1/20 | 0.60 |
| ▸ | CA1 | P00915 | 1/20 | 0.60 |
| ▸ | CA2 | P00918 | 1/20 | 0.60 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.60 |
| ▸ | HPGD | P15428 | 1/20 | 0.60 |
| ▸ | CA4 | P22748 | 1/20 | 0.60 |
| ▸ | CA6 | P23280 | 1/20 | 0.60 |
| ▸ | CA7 | P43166 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
| ▸ | CA9 | Q16790 | 1/20 | 0.60 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.60 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.60 |
| ▸ | NAAA | Q02083 | 1/20 | 0.49 |
| ▸ | HDAC11 | Q96DB2 | 6/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Decanoic Acid SCHEMBL31329255 | 0.95 | ALDH1A1 (0.58) | ALDH1A1KDM4ECA12CA1CA2 | |
| Octanoic Acid SCHEMBL29194737 | 0.95 | ALDH1A1 (0.58) | ALDH1A1KDM4ECA12CA1CA2 | |
| Stearic Acid SCHEMBL28601506 | 0.95 | ALDH1A1 (0.58) | ALDH1A1KDM4ECA12CA1CA2 | |
| Myristic Acid SCHEMBL28173391 | 0.95 | ALDH1A1 (0.58) | ALDH1A1KDM4ECA12CA1CA2 | |
| Palmitic Acid SCHEMBL1858146 | 0.95 | ALDH1A1 (0.58) | ALDH1A1KDM4ECA12CA1CA2 | |
| Dodecanoate SCHEMBL28954208 | 0.94 | ALDH1A1 (0.56) | ALDH1A1KDM4ECA12CA1CA2 | |
| Salicylic Acid SCHEMBL28538392 | 0.93 | ALDH1A1 (0.60) | ALDH1A1KDM4ECA12CA1CA2 | |
| Sebacic Acid SCHEMBL9136782 | 0.93 | ALDH1A1 (0.69) | ALDH1A1KDM4ECA12CA1CA2 | |
| Sebacic Acid SCHEMBL29764185 | 0.93 | ALDH1A1 (0.69) | ALDH1A1KDM4ECA12CA1CA2 | |
| Adipic Acid SCHEMBL19349213 | 0.91 | ALDH1A1 (0.72) | ALDH1A1KDM4ECA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11033491-B2 | Dicarboxylic acid foamable vehicle and pharmaceutical compositions thereof | VYNE THERAPEUTICS INC. (US) | 2021-06-15 | — | — | US | disclosed |
| US-20210038517-A1 | DICARBOXYLIC ACID FOAMABLE VEHICLE AND PHARMACEUTICAL COMPOSITIONS THEREOF | VYNE THERAPEUTICS INC. (F/K/A MENLO THERAPEUTICS INC. AND SUCCESSOR-IN-INTEREST TO VYNE PHARMACEUTICALS LTD., F/K/A FOAMIX PHARMACEUTICALS LTD.) | 2021-02-11 | — | — | US | disclosed |
| US-10821077-B2 | Dicarboxylic acid foamable vehicle and pharmaceutical compositions thereof | FOAMIX PHARMACEUTICALS LTD. (IL) | 2020-11-03 | — | — | US | disclosed |
| US-20200078298-A1 | Dicarboxylic Acid Foamable Vehicle and Pharmaceutical Compositions Thereof | FOAMIX PHARMACEUTICALS LTD. | 2020-03-12 | — | — | US | disclosed |
| US-20190247310-A9 | DICARBOXYLIC ACID FOAMABLE VEHICLE AND PHARMACEUTICAL COMPOSITIONS THEREOF | FOAMIX PHARMACEUTICALS LTD. (IL) | 2019-08-15 | — | — | US | disclosed |
| US-10322085-B2 | Dicarboxylic acid foamable vehicle and pharmaceutical compositions thereof | FOAMIX PHARMACEUTICALS LTD. (IL) | 2019-06-18 | — | — | US | disclosed |
| US-20190076356-A1 | Dicarboxylic Acid Foamable Vehicle and Pharmaceutical Compositions Thereof | VYNE THERAPEUTICS INC. (F/K/A MENLO THERAPEUTICS INC. AND SUCCESSOR-IN-INTEREST TO VYNE PHARMACEUTICALS LTD., F/K/A FOAMIX PHARMACEUTICALS LTD.) | 2019-03-14 | — | — | US | disclosed |
| US-20190022001-A1 | DICARBOXYLIC ACID FOAMABLE VEHICLE AND PHARMACEUTICAL COMPOSITIONS THEREOF | FOAMIX PHARMACEUTICALS LTD. (IL) | 2019-01-24 | — | — | US | disclosed |
| US-9265725-B2 | Dicarboxylic acid foamable vehicle and pharmaceutical compositions thereof | FOAMIX PHARMACEUTICALS LTD. (IL) | 2016-02-23 | — | — | US | disclosed |
| US-20130189195-A1 | DICARBOXYLIC ACID FOAMABLE VEHICLE AND PHARMACEUTICAL COMPOSITIONS THEREOF | FOAMIX LTD. (IL) | 2013-07-25 | — | — | US | disclosed |
| EP-2494959-A1 | Dicarboxylic acid foamable vehicle and pharmaceutical compositions thereof | Foamix Ltd. (IL) | 2012-09-05 | — | — | EP | disclosed |
| EP-2051697-A2 | FOAMABLE VEHICLE COMPRISING DICARBOXYLIC ACID OR DICARBOXYLIC ACID ESTER AND PHARMACEUTICAL COMPOSITIONS THEREOF | Foamix Ltd. (IL) | 2009-04-29 | — | — | EP | disclosed |
| WO-2008038147-A2 | FOAMABLE VEHICLE COMPRISING DICARBOXYLIC ACID OR DICARBOXYLIC ACID ESTER AND PHARMACEUTICAL COMPOSITIONS THEREOF | FOAMIX LTD. (US) | 2008-04-03 | — | — | WO | disclosed |
| US-20080044444-A1 | Dicarboxylic acid foamable vehicle and pharmaceutical compositions thereof | FOAMIX LTD. (IL) | 2008-02-21 | — | — | US | disclosed |