SCHEMBL4039484

SCHEMBL4039484

CCCNC(=O)C(CCC)C1(c2ccc(O)cc2)Nc2ccccc2N1

nearest known ligand 0.37

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CNR1 P21554 1/20 0.37
CNR2 P34972 1/20 0.37
HPGD P15428 1/20 0.36
L3MBTL1 Q9Y468 2/20 0.35
GPR88 Q9GZN0 1/20 0.33
GLI1 P08151 1/20 0.33
GLI2 P10070 1/20 0.33
TP53 P04637 1/20 0.32
NAAA Q02083 2/20 0.32
EPHX1 P07099 1/20 0.32
CHRM2 P08172 1/20 0.32
ADORA3 P0DMS8 1/20 0.32
KCNH2 Q12809 1/20 0.32
ALDH1A1 P00352 1/20 0.32
GAA P10253 1/20 0.32
POLB P06746 1/20 0.32
SLC6A2 P23975 1/20 0.32
SLC6A3 Q01959 1/20 0.32
JAK2 O60674 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4043928 0.82 L3MBTL1 (0.35) HPGDL3MBTL1NAAAALDH1A1GAA
SCHEMBL4039204 0.69 TSHR (0.43) HPGDALDH1A1POLB
SCHEMBL4041182 0.66 BCHE (0.42) TP53EPHX1ALDH1A1
SCHEMBL4037816 0.65 HPGD (0.38) HPGDALDH1A1POLB
SCHEMBL9461596 0.64 CNR1 (0.62) CNR1CNR2TP53CHRM2ADORA3
SCHEMBL4038755 0.63 HPGD (0.43) HPGDNAAAALDH1A1
Dimethylamine SCHEMBL9167323 0.62 CNR1 (0.59) CNR1CNR2TP53ALDH1A1
SCHEMBL9054297 0.60 SLC7A5 (0.56)
SCHEMBL6432979 0.59 CNR1 (0.69) CNR1CNR2ALDH1A1
Phenol SCHEMBL8803835 0.59 BCAT2 (0.47) HPGDL3MBTL1TP53NAAAEPHX1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2038259-A1 BENZIMIDAZOLE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, THEIR USE AS FXR AGONISTS AND PHARMACEUTICAL PREPARATIONS CONTAINING THE SAME F.HOFFMANN-LA ROCHE AG (CH) 2009-03-25 EP claimed
WO-2008000643-A1 BENZIMIDAZOLE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, THEIR USE AS FXR AGONISTS AND PHARMACEUTICAL PREPARATIONS CONTAINING THE SAME F. HOFFMANN-LA ROCHE AG (CH) 2008-01-03 WO claimed
EP-3043865-A1 METHODS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF HEPATITIS B VIRUS INFECTION Institut National de la Santé et de la Recherche Médicale (INSERM) (FR) 2016-07-20 EP disclosed
WO-2015036442-A1 METHODS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF HEPATITIS B VIRUS INFECTION INSERM (Institut National de la Santé et de la Recherche Médicale) (FR) 2015-03-19 WO disclosed
EP-2038259-A1 BENZIMIDAZOLE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, THEIR USE AS FXR AGONISTS AND PHARMACEUTICAL PREPARATIONS CONTAINING THE SAME F.HOFFMANN-LA ROCHE AG (CH) 2009-03-25 EP disclosed
WO-2008000643-A1 BENZIMIDAZOLE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, THEIR USE AS FXR AGONISTS AND PHARMACEUTICAL PREPARATIONS CONTAINING THE SAME F. HOFFMANN-LA ROCHE AG (CH) 2008-01-03 WO disclosed