Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.58 |
| ▸ | PLK1 | P53350 | 2/20 | 0.57 |
| ▸ | CA1 | P00915 | 1/20 | 0.56 |
| ▸ | CA2 | P00918 | 1/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.53 |
| ▸ | KDM1A | O60341 | 2/20 | 0.53 |
| ▸ | HTR1D | P28221 | 1/20 | 0.53 |
| ▸ | HTR1B | P28222 | 1/20 | 0.53 |
| ▸ | MMP1 | P03956 | 1/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9629138 | 0.88 | PLK1 (0.73) | NPC1PLK1HTR1DHTR1BKDM4E | |
| SCHEMBL25581165 | 0.84 | NPC1 (0.55) | NPC1PLK1CA1CA2HTR1D | |
| SCHEMBL6671125 | 0.83 | MMP1 (0.72) | PLK1HDAC6MMP1KDM4ETSHR | |
| SCHEMBL10065842 | 0.83 | TSHR (0.71) | NPC1HTR1DHTR1BKDM4EALDH1A1 | |
| SCHEMBL14880162 | 0.83 | PLK1 (0.75) | NPC1PLK1CA1CA2MMP1 | |
| SCHEMBL5141541 | 0.83 | L3MBTL1 (0.70) | NPC1PLK1HTR1DHTR1BKDM4E | |
| SCHEMBL24600195 | 0.83 | NPC1 (0.66) | NPC1PLK1MMP1KDM4EMEN1 | |
| SCHEMBL12966671 | 0.83 | NPC1 (0.54) | NPC1PLK1HTR1DHTR1BKDM4E | |
| SCHEMBL5051932 | 0.82 | GAA (0.61) | PLK1CA1CA2HDAC6KDM1A | |
| SCHEMBL13715503 | 0.81 | PARP10 (0.62) | NPC1PLK1CA1CA2HTR1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1611088-B1 | HYDROXAMATES AS THERAPEUTIC AGENTS | PHARMACYCLICS INC (US) | 2009-06-17 | — | — | EP | claimed |