Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Mitotane. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 7/20 | 1.00 |
| ▸ | HIF1A | Q16665 | 4/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 4/20 | 1.00 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 1.00 |
| ▸ | CNR1 | P21554 | 4/20 | 1.00 |
| ▸ | LMNA | P02545 | 3/20 | 1.00 |
| ▸ | ATM | Q13315 | 2/20 | 1.00 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 1.00 |
| ▸ | CYP2C19 | P33261 | 2/20 | 1.00 |
| ▸ | CYP2C9 | P11712 | 1/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 1.00 |
| ▸ | NR1I2 | O75469 | 1/20 | 1.00 |
| ▸ | ABCB11 | O95342 | 1/20 | 1.00 |
| ▸ | NR3C1 | P04150 | 1/20 | 1.00 |
| ▸ | PGR | P06401 | 1/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 1/20 | 1.00 |
| ▸ | ADRA2A | P08913 | 1/20 | 1.00 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 1.00 |
| ▸ | MAPT | P10636 | 1/20 | 1.00 |
| ▸ | SLC6A2 | P23975 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Mitotane SCHEMBL29360948 | 1.00 | TSHR (1.00) | TSHRHIF1AMAPK1TDP1CNR1 | |
| Mitotane SCHEMBL2352082 | 1.00 | TSHR (1.00) | TSHRHIF1AMAPK1TDP1CNR1 | |
| Mitotane SCHEMBL4041 | 1.00 | TSHR (1.00) | TSHRHIF1AMAPK1TDP1CNR1 | |
| Mitotane SCHEMBL8937953 | 0.88 | CNR1 (0.78) | TSHRHIF1AMAPK1TDP1CNR1 | |
| Mitotane SCHEMBL8465001 | 0.87 | CNR1 (0.76) | TSHRHIF1AMAPK1TDP1CNR1 | |
| SCHEMBL29502468 | 0.85 | TSHR (0.73) | TSHRHIF1AMAPK1TDP1CNR1 | |
| SCHEMBL9130061 | 0.83 | TSHR (0.69) | TSHRHIF1AMAPK1TDP1CNR1 | |
| SCHEMBL7873189 | 0.79 | TSHR (0.66) | TSHRHIF1AMAPK1TDP1CNR1 | |
| Diethylstilbestrol SCHEMBL534253 | 0.79 | TSHR (0.62) | TSHRHIF1AMAPK1TDP1CNR1 | |
| SCHEMBL2937089 | 0.79 | TSHR (0.81) | TSHRHIF1AMAPK1TDP1CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 87208 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4748859-A2 | CHEMICALLY AND PHOTOCHEMICALLY INITIATED CELL MEMBRANE BLEBBING TO INDUCE CELL VESICLE PRODUCTION, MODIFICATIONS THEREOF, AND USES THEREOF | The Regents of the University of California (US) | 2026-05-27 | — | — | EP | claimed |
| EP-4747611-A1 | OPTICAL ELECTRODE ANALYTE DETECTION SYSTEM AND METHODS OF USE | Vital Biosciences Inc. (CA) | 2026-05-27 | — | — | EP | claimed |
| EP-4747263-A1 | LIPID NANOPARTICLES AND USES THEREOF | University of Connecticut (US) | 2026-05-27 | — | — | EP | claimed |
| CN-116209439-B | Cereblon protein modulators | Saint Jude Children's Research Hospital Ltd. (US) | 2026-05-26 | — | — | CN | claimed |
| US-20260137794-A1 | LIGAND-DRUG CONJUGATE AND USE THEREOF | SYSTIMMUNE INC (US) | 2026-05-21 | — | — | US | claimed |
| WO-2026105121-A1 | ANTICANCER FORMULATIONS AND USES THEREOF | INTRAGEL THERAPEUTICS LTD. (IL) | 2026-05-21 | — | — | WO | claimed |
| EP-4743490-A1 | HUMANIZED ANTI-CD7 ANTIBODY | Christian-Albrechts-Universität zu Kiel (DE) | 2026-05-20 | — | — | EP | claimed |
| CN-122056884-A | Methods of treating pancreatic cancer | 坎莫森特里克斯公司 | 2026-05-19 | — | — | CN | claimed |
| WO-2026099502-A1 | NOVEL DRUG CONJUGATES FOR TESTING CELLULAR DRUG UPTAKE | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts (DE) | 2026-05-15 | — | — | WO | claimed |
| WO-2026102332-A1 | NERVE AND TUMOR HOMING AGENTS AND METHODS OF USE THEREOF | Blaze Bioscience, Inc. (US) | 2026-05-15 | — | — | WO | claimed |
| WO-1994020072-A1 | SOLID LIPID PARTICLES, PARTICLES OF BIOACTIVE AGENTS AND METHODS FOR THE MANUFACTURE AND USE THEREOF | PHARMACIA AB (SE) | 1994-09-15 | — | — | WO | claimed |
| WO-1994013277-A2 | USE OF DINAPHTHALENES COMPOUNDS AS ANTIPROLIFERATIVE AGENTS | IMPERIAL CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 1994-06-23 | — | — | WO | claimed |
| EP-0393575-B1 | Neoplasia treatment compositions containing antineoplastic agent and side-effect reducing protective agent | SEARLE & CO (US) | 1994-03-16 | — | — | EP | claimed |
| WO-1994004702-A2 | IMPROVED DETECTION AND THERAPY OF LESIONS WITH BIOTIN/AVIDIN CONJUGATES | IMMUNOMEDICS, INC. (US) | 1994-03-03 | — | — | WO | claimed |
| WO-1993019668-A1 | METHOD AND KIT FOR IMAGING AND TREATING ORGANS AND TISSUES | IMMUNOMEDICS, INC. (US) | 1993-10-14 | — | — | WO | claimed |
| EP-0393575-A1 | Neoplasia treatment compositions containing antineoplastic agent and side-effect reducing protective agent | G.D. Searle & Co. (US) | 1990-10-24 | — | — | EP | claimed |
| EP-0227593-A1 | Use of chelating agents | THE HOSPITAL FOR SICK CHILDREN (CA) | 1987-07-01 | — | — | EP | claimed |
| EP-0010964-A1 | Ravidomycin, process of preparation and pharmaceutical compositions containing same | AYERST, MCKENNA AND HARRISON INC. (CA) | 1980-05-14 | — | — | EP | claimed |
| US-4146648-A | 1,1-DICHLORO-2-(O-CHLOROPHENYL)-2-(P-CHLOROPHENYL)ETHANE IN AN OIL CARRIER FOR TREATING ADRENAL CORTICAL CARCINOMA | BRISTOL-MYERS COMPANY (US) | 1979-03-27 | — | — | US | claimed |
| US-4133893-A | 1,1-DICHLORO-2-/O-CHLOROPHENYL/-2-/P-CHLOROPHENYL/ETHANE | CALBIOCHEM BEHRING CORP. (US) | 1979-01-09 | — | — | US | claimed |