Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Mitotane. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 7/20 | 0.76 |
| ▸ | TSHR | P16473 | 4/20 | 0.76 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.76 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.76 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.76 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.76 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.76 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.76 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.76 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.76 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.76 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.76 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.76 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.76 |
| ▸ | LMNA | P02545 | 1/20 | 0.76 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.76 |
| ▸ | PGR | P06401 | 1/20 | 0.76 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.76 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.76 |
| ▸ | MAPT | P10636 | 1/20 | 0.76 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Mitotane SCHEMBL8937953 | 0.92 | CNR1 (0.78) | CNR1TSHRHIF1AMAPK1TDP1 | |
| Mitotane SCHEMBL2352082 | 0.87 | TSHR (1.00) | CNR1TSHRHIF1AMAPK1TDP1 | |
| Mitotane SCHEMBL4040 | 0.87 | TSHR (1.00) | CNR1TSHRHIF1AMAPK1TDP1 | |
| Mitotane SCHEMBL29360948 | 0.87 | TSHR (1.00) | CNR1TSHRHIF1AMAPK1TDP1 | |
| Mitotane SCHEMBL4041 | 0.87 | TSHR (1.00) | CNR1TSHRHIF1AMAPK1TDP1 | |
| SCHEMBL25502360 | 0.74 | TSHR (0.73) | CNR1TSHRHIF1AMAPK1TDP1 | |
| SCHEMBL29502468 | 0.74 | TSHR (0.73) | CNR1TSHRHIF1AMAPK1TDP1 | |
| SCHEMBL9130061 | 0.72 | TSHR (0.69) | CNR1TSHRHIF1AMAPK1TDP1 | |
| Diethylstilbestrol SCHEMBL534253 | 0.72 | TSHR (0.62) | CNR1TSHRHIF1AMAPK1TDP1 | |
| 1,2-Dichlorobenzene SCHEMBL28643400 | 0.70 | LMNA (0.56) | TSHRMAPK1TDP1CYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5871724-A | ADMINISTERING TO THE SUBJECT AN AMOUNT OF A TRANSFORMING GROWTH FACTOR BETA 3 EFFECTIVE TO SLOW THE GROWTH OF NORMAL CELLS | O.S.I. PHARMACEUTICALS INC. (US) | 1999-02-16 | — | — | US | disclosed |