Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 8/20 | 0.54 |
| ▸ | CTSS | P25774 | 3/20 | 0.43 |
| ▸ | CTSV | O60911 | 2/20 | 0.43 |
| ▸ | CTSL | P07711 | 2/20 | 0.43 |
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.34 |
| ▸ | HTRA1 | Q92743 | 6/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4046758 | 0.92 | CTSK (0.65) | CTSKCTSSCTSVCTSL | |
| SCHEMBL4048667 | 0.91 | CTSK (0.54) | CTSKCTSSCTSVCTSL | |
| SCHEMBL4040998 | 0.89 | CTSK (0.52) | CTSKCTSS | |
| SCHEMBL4043294 | 0.89 | CTSS (0.44) | CTSKCTSSCTSVCTSLHTRA1 | |
| SCHEMBL4037036 | 0.89 | CTSK (0.54) | CTSKCTSSCTSVCTSLUSP30 | |
| SCHEMBL4045568 | 0.89 | CTSK (0.52) | CTSKCTSSUSP30 | |
| SCHEMBL4039133 | 0.88 | CTSK (0.51) | CTSKCTSSCTSVCTSLUSP30 | |
| SCHEMBL4039714 | 0.87 | CTSK (0.51) | CTSKCTSSUSP30 | |
| SCHEMBL4047934 | 0.87 | CTSK (0.51) | CTSKCTSSCTSL | |
| SCHEMBL4045746 | 0.87 | CTSS (0.40) | CTSKCTSSCTSVCTSLHTRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546150-B1 | PYRROLE DERIVATIVES AS INHIBITORS OF CYTEINE PROTEASES | AMURA THERAPEUTICS LTD (GB) | 2009-03-04 | — | — | EP | claimed |
| EP-1546150-A1 | BIOLOGICALLY ACTIVE COMPOUNDS | Amura Therapeutics Limited (GB) | 2005-06-29 | — | — | EP | claimed |
| WO-2004007501-A1 | BIOLOGICALLY ACTIVE COMPOUNDS | AMURA THERAPEUTICS LIMITED (GB) | 2004-01-22 | — | — | WO | claimed |
| EP-2010523-A1 | SPIROCOMPOUNDS USEFUL AS MODULATORS FOR DOPAMINE D3 RECEPTORS | GLAXO GROUP LIMITED (GB) | 2009-01-07 | — | — | EP | disclosed |
| WO-2007125061-A1 | SPIROCOMPOUNDS USEFUL AS MODULATORS FOR DOPAMINE D3 RECEPTORS | GLAXO GROUP LIMITED (GB) | 2007-11-08 | — | — | WO | disclosed |