Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 18/20 | 0.67 |
| ▸ | SYK | P43405 | 1/20 | 0.47 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3946128 | 0.86 | TGFBR1 (0.63) | TGFBR1ABCG2 | |
| SCHEMBL3944990 | 0.85 | TGFBR1 (0.62) | TGFBR1 | |
| SCHEMBL3949465 | 0.84 | TGFBR1 (0.61) | TGFBR1 | |
| SCHEMBL3947619 | 0.84 | TGFBR1 (0.61) | TGFBR1 | |
| SCHEMBL3946522 | 0.84 | TGFBR1 (0.61) | TGFBR1 | |
| SCHEMBL3955188 | 0.84 | TGFBR1 (0.61) | TGFBR1ABCG2 | |
| SCHEMBL3947614 | 0.83 | TGFBR1 (0.60) | TGFBR1 | |
| SCHEMBL3948197 | 0.83 | TGFBR1 (0.65) | TGFBR1 | |
| SCHEMBL4187880 | 0.82 | TGFBR1 (0.59) | TGFBR1 | |
| SCHEMBL3953868 | 0.82 | TGFBR1 (0.79) | TGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090048269-A1 | CHEMICAL COMPOUNDS-821 | ASTRAZENECA AB (SE) | 2009-02-19 | — | — | US | disclosed |
| WO-2009022171-A1 | PYRIDINYIIOXY PYRIDINES AS ALK5 INHIBITORS | ASTRAZENECA AB (SE) | 2009-02-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090048269-A1 | CHEMICAL COMPOUNDS-821 | TGFBR1, TGFBR2, SMAD3 | TGFBR1 1/4885SYK 900/4885ABCG2 968/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.