Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 5/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.42 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.42 |
| ▸ | NAAA | Q02083 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | ITGAV | P06756 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2485496 | 0.74 | TRPM8 (0.44) | ALDH1A1LMNAMTNR1AMTNR1BTP53 | |
| SCHEMBL3884172 | 0.74 | GAA (0.55) | HPGDALDH1A1POLBLMNAGAA | |
| Hydrochloric Acid SCHEMBL2485467 | 0.73 | TRPM8 (0.43) | ALDH1A1LMNAMTNR1AMTNR1BTP53 | |
| SCHEMBL168006 | 0.72 | GAA (0.61) | HPGDALDH1A1POLBLMNAGAA | |
| SCHEMBL27456060 | 0.72 | EPHX1 (0.46) | HPGDALDH1A1POLBGAASMN1; SMN2 | |
| SCHEMBL28683590 | 0.71 | GAA (0.55) | HPGDALDH1A1POLBLMNAGAA | |
| SCHEMBL14823336 | 0.71 | GAA (0.59) | HPGDALDH1A1POLBLMNAGAA | |
| SCHEMBL20670268 | 0.70 | MAPT (0.42) | ALDH1A1LMNATP53CYP3A4NPSR1 | |
| SCHEMBL29016424 | 0.69 | GAA (0.57) | HPGDALDH1A1POLBLMNAGAA | |
| SCHEMBL10540980 | 0.69 | TRPM8 (0.47) | ALDH1A1LMNATP53TDP1ITGAV |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2010508-A1 | THIAZOL-GUANIDINE DERIVATIVES USEFUL AS A (BETA)- RELATED PATHOLOGIES | AstraZeneca AB (SE) | 2009-01-07 | — | — | EP | disclosed |
| WO-2007120096-A1 | THIAZOL-GUANIDINE DERIVATIVES USEFUL AS A (BETA)- RELATED PATHOLOGIES | ASTRAZENECA AB (SE) | 2007-10-25 | — | — | WO | disclosed |