Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 3/20 | 0.34 |
| ▸ | MC4R | P32245 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | TMPRSS11D | O60235 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4039499 | 0.92 | CTSK (0.35) | CTSKALDH1A1GAAKMT2ALMNA | |
| SCHEMBL4039943 | 0.91 | POLB (0.35) | CTSKALDH1A1GAAKMT2ALMNA | |
| SCHEMBL4045822 | 0.89 | KDM4E (0.40) | CTSKALDH1A1GAAKMT2APKM | |
| SCHEMBL4040674 | 0.88 | POLB (0.37) | ALDH1A1KMT2ALMNAPKMSMN1; SMN2 | |
| SCHEMBL4043419 | 0.88 | CTSK (0.33) | CTSK | |
| SCHEMBL4041865 | 0.88 | ALDH1A1 (0.34) | CTSKMC4RALDH1A1GAAKMT2A | |
| SCHEMBL4040117 | 0.86 | CTSK (0.32) | CTSK | |
| SCHEMBL4044086 | 0.83 | CTSK (0.40) | CTSK | |
| SCHEMBL4041828 | 0.82 | CTSK (0.35) | CTSKMC4RALDH1A1GAAKMT2A | |
| SCHEMBL6211805 | 0.81 | CTSK (0.35) | CTSKMC4RALDH1A1GAAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546150-B1 | PYRROLE DERIVATIVES AS INHIBITORS OF CYTEINE PROTEASES | AMURA THERAPEUTICS LTD (GB) | 2009-03-04 | — | — | EP | claimed |
| EP-1546150-A1 | BIOLOGICALLY ACTIVE COMPOUNDS | Amura Therapeutics Limited (GB) | 2005-06-29 | — | — | EP | claimed |
| WO-2004007501-A1 | BIOLOGICALLY ACTIVE COMPOUNDS | AMURA THERAPEUTICS LIMITED (GB) | 2004-01-22 | — | — | WO | claimed |
| EP-1463728-B1 | FUSED CYCLIC MODULATORS OF NUCLEAR HORMONE RECEPTOR FUNCTION | BRISTOL MYERS SQUIBB CO (US) | 2009-01-14 | — | — | EP | disclosed |