Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | MMP1 | P03956 | 2/20 | 0.42 |
| ▸ | FCER2 | P06734 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.40 |
| ▸ | KLK7 | P49862 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1840331 | 0.91 | EPHX1 (0.42) | EPHX1HPGDRAB9ANPC1MMP1 | |
| SCHEMBL1842066 | 0.87 | OPRL1 (0.39) | ALDH1A1LMNAMDM2 | |
| SCHEMBL3653824 | 0.84 | CCR1 (0.37) | EPHX1RAB9ANPC1ALDH1A1SMN1; SMN2 | |
| SCHEMBL4041182 | 0.84 | BCHE (0.42) | EPHX1ALDH1A1KMT2A | |
| SCHEMBL4044540 | 0.84 | NR1H4 (0.44) | EPHX1HPGDRAB9ANPC1ALDH1A1 | |
| SCHEMBL4039101 | 0.84 | NR1H4 (0.44) | EPHX1HPGDRAB9ANPC1ALDH1A1 | |
| SCHEMBL4042732 | 0.84 | NR1H4 (0.44) | EPHX1HPGDRAB9ANPC1ALDH1A1 | |
| SCHEMBL4040480 | 0.84 | NR1H4 (0.44) | EPHX1HPGDRAB9ANPC1ALDH1A1 | |
| SCHEMBL4037882 | 0.82 | CTSD (0.36) | EPHX1RAB9ANPC1MMP1SMN1; SMN2 | |
| SCHEMBL4037898 | 0.79 | NR1H4 (0.51) | EPHX1HPGDRAB9ANPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2038259-A1 | BENZIMIDAZOLE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, THEIR USE AS FXR AGONISTS AND PHARMACEUTICAL PREPARATIONS CONTAINING THE SAME | F.HOFFMANN-LA ROCHE AG (CH) | 2009-03-25 | — | — | EP | disclosed |
| WO-2008000643-A1 | BENZIMIDAZOLE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, THEIR USE AS FXR AGONISTS AND PHARMACEUTICAL PREPARATIONS CONTAINING THE SAME | F. HOFFMANN-LA ROCHE AG (CH) | 2008-01-03 | — | — | WO | disclosed |