Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | CTSD | P07339 | 1/20 | 0.40 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.39 |
| ▸ | KLK7 | P49862 | 1/20 | 0.38 |
| ▸ | MMP1 | P03956 | 1/20 | 0.38 |
| ▸ | FCER2 | P06734 | 1/20 | 0.38 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.38 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.38 |
| ▸ | OGT | O15294 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1842066 | 0.96 | OPRL1 (0.39) | CTSDADAM17SCN5ASCN9AMDM2 | |
| SCHEMBL4040798 | 0.91 | EPHX1 (0.47) | EPHX1HPGDNPC1RAB9ACPB2 | |
| SCHEMBL1840250 | 0.83 | TP53 (0.36) | NPC1RAB9AMDM2 | |
| SCHEMBL1838714 | 0.82 | TP53 (0.38) | EPHX1NPC1RAB9AMDM2 | |
| SCHEMBL4035029 | 0.81 | NR1H4 (0.47) | EPHX1HPGDNPC1RAB9A | |
| SCHEMBL4040844 | 0.81 | NR1H4 (0.47) | EPHX1HPGDNPC1RAB9A | |
| SCHEMBL1839859 | 0.81 | AGER (0.37) | MDM2 | |
| SCHEMBL4043373 | 0.80 | CTSD (0.36) | EPHX1CTSD | |
| SCHEMBL1838873 | 0.79 | SLC6A3 (0.42) | MDM2 | |
| SCHEMBL3655058 | 0.79 | NR1H4 (0.54) | EPHX1NPC1RAB9AKLK7MDM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2321282-A1 | NEW BENZIMIDAZOLE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2011-05-18 | — | — | EP | disclosed |
| WO-2010028981-A1 | NEW BENZIMIDAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2010-03-18 | — | — | WO | disclosed |