Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 10/20 | 0.50 |
| ▸ | IL6 | P05231 | 4/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.44 |
| ▸ | USP2 | O75604 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | CASP1 | P29466 | 2/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CASP7 | P55210 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4035856 | 0.90 | TLR7 (0.49) | TLR7IL6 | |
| SCHEMBL3945618 | 0.74 | ALDH1A1 (0.43) | TLR7CYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL13274936 | 0.74 | TLR7 (0.67) | TLR7IL6CYP3A4 | |
| SCHEMBL3947510 | 0.73 | TLR7 (0.49) | TLR7IL6 | |
| SCHEMBL13275562 | 0.72 | TLR7 (0.64) | TLR7IL6 | |
| SCHEMBL1146212 | 0.71 | TLR7 (0.79) | TLR7IL6 | |
| SCHEMBL34462360 | 0.70 | TLR7 (0.54) | TLR7IL6 | |
| SCHEMBL3945621 | 0.70 | TLR7 (0.37) | TLR7KMT2ATSHR | |
| SCHEMBL13274307 | 0.70 | TLR7 (0.64) | TLR7IL6 | |
| SCHEMBL4038955 | 0.69 | TLR9 (0.68) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009022185-A2 | 6, 6-FUSED HETEROCYCLES, THEIR PHARMACEUTICAL COMPOSITIONS AND METHOS OF USE | ASTRAZENECA AB (SE) | 2009-02-19 | — | — | WO | claimed |
| WO-2009022185-A2 | 6, 6-FUSED HETEROCYCLES, THEIR PHARMACEUTICAL COMPOSITIONS AND METHOS OF USE | ASTRAZENECA AB (SE) | 2009-02-19 | — | — | WO | disclosed |