SCHEMBL40410

SCHEMBL40410

COC[Si](C)(C)c1ccccc1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 1/20 0.41
ESR1 P03372 1/20 0.37
ESR2 Q92731 1/20 0.37
MGAM O43451 2/20 0.36
CA4 P22748 2/20 0.35
NR1H2 P55055 2/20 0.33
NR1H3 Q13133 2/20 0.33
CA2 P00918 2/20 0.31
POLB P06746 2/20 0.31
LTA4H P09960 2/20 0.31
KCNH3 Q9ULD8 1/20 0.31
CA12 O43570 1/20 0.31
CA1 P00915 1/20 0.31
CA7 P43166 1/20 0.31
CA9 Q16790 1/20 0.31
CA14 Q9ULX7 1/20 0.31
NPC1 O15118 1/20 0.31
RAB9A P51151 1/20 0.31
LMNA P02545 1/20 0.31
NR1I2 O75469 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2547799 0.82 MAPT (0.39) MAPTESR1ESR2MGAMCA4
SCHEMBL2274337 0.81 ESR1 (0.37) MAPTESR1ESR2CA4NR1H2
SCHEMBL2276981 0.80 CA4 (0.38) MAPTESR1ESR2CA4CA2
SCHEMBL40408 0.79 MAPT (0.40) MAPTESR1ESR2MGAMNR1H2
Hydrochloric Acid SCHEMBL10398554 0.78 MAPT (0.42) MAPTESR1ESR2MGAMCA4
SCHEMBL11316383 0.77 MAPT (0.39) MAPTESR1ESR2MGAMNR1H2
SCHEMBL869282 0.77 MAPT (0.39) MAPTESR1ESR2MGAMNR1H2
SCHEMBL16325251 0.76 MAPT (0.38) MAPTESR1ESR2MGAMNR1H2
SCHEMBL2355439 0.76 MAPT (0.42) MAPTESR1ESR2MGAMNR1H2
SCHEMBL1470884 0.76 MAPT (0.38) MAPTESR1ESR2MGAMNR1H2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 4367 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2991655-B1 COMPOSITIONS AND METHODS FOR ALTERING SECOND MESSENGER SIGNALING MEMORIAL SLOAN KETTERING CANCER CENTER (US) 2024-04-10 EP claimed
US-20230374060-A1 NOVEL METHOD FOR PREPARING INOTODIOL DAEGU-GYEONGBUK MEDICAL INNOVATION FOUNDATION (KR) 2023-11-23 US claimed
EP-3606528-B1 TRICYCLIC COMPOUNDS AS GLYCOGEN SYNTHASE KINASE 3 (GSK3) INHIBITORS AND USES THEREOF BROAD INST INC (US) 2023-10-18 EP claimed
EP-4130020-A1 NOVEL METHOD FOR PREPARING INOTODIOL Daegu-Gyeongbuk Medical Innovation Foundation (KR) 2023-02-08 EP claimed
EP-3649135-B1 SYNTHESIS OF HALICHONDRINS HARVARD COLLEGE (US) 2022-12-28 EP claimed
US-11241435-B2 Uses of salt-inducible kinase (SIK) inhibitors for treating osteoporosis THE GENERAL HOSPITAL CORPORATION (US) 2022-02-08 US claimed
EP-3172213-B1 MACROCYCLIC KINASE INHIBITORS AND USES THEREOF DANA FARBER CANCER INST INC (US) 2021-09-22 EP claimed
US-10981849-B1 Method for preparing cannabinoids SCI PHARMTECH INC. (TW) 2021-04-20 US claimed
EP-3092220-B1 VITAMIN C PRODRUGS AND USES THEREOF UNIV FLORIDA (US) 2021-01-20 EP claimed
US-10870651-B2 Inhibitors of cyclin-dependent kinase 7 (CDK7) DANA-FARBER CANCER INSTITUTE, INC. (US) 2020-12-22 US claimed
WO-2007143635-A1 METHOD TO PREPARE PURE CURCUMIN KIM DARRICK S (US) 2007-12-13 WO claimed
EP-1594835-A4 METHOD OF PREPARATION OF HETEROCYCLIC MOLECULES WITH PHARMACEUTICAL PHARMACEUTICAL EXCIPIENT COSMECEUTICAL AGROCHEMICAL AND INDUSTRIAL USES AUSPEX PHARMACEUTICALS INC (US) 2007-05-02 EP claimed
EP-1740522-A2 BISPHENYL COMPOUNDS USEFUL AS VITAMIN D SB 3 /SB RECEPTOR AGONISTS CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2007-01-10 EP claimed
US-20060173199-A1 Method of preparation of heterocyclic molecules with pharmaceutical, pharmaceutical excipient, cosmeceutical, agrochemical and industrial uses HONG BORCHERNG 2006-08-03 US claimed
US-20060025474-A1 Bisphenyl compounds useful as vitamin D3 receptor agonists CHUGAI SEIYAKU KABUSHIKA KAISHA (JP) 2006-02-02 US claimed
EP-1594835-A2 METHOD OF PREPARATION OF HETEROCYCLIC MOLECULES WITH PHARMACEUTICAL PHARMACEUTICAL EXCIPIENT COSMECEUTICAL AGROCHEMICAL AND INDUSTRIAL USES Auspex Pharmaceuticals, Inc. (US) 2005-11-16 EP claimed
WO-2005087700-A2 BISPHENYL COMPOUNDS USEFUL AS VITAMIN D3 RECEPTOR AGONISTS CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2005-09-22 WO claimed
WO-2004064745-A2 METHOD OF PREPARATION OF HETEROCYCLIC MOLECULES WITH PHARMACEUTICAL PHARMACEUTICAL EXCIPIENT COSMECEUTICAL AGROCHEMICAL AND INDUSTRIAL USES AUSPEX PHARMACEUTICALS, INC. (US) 2004-08-05 WO claimed
US-5726195-A Aminoacyl adenylate mimics as novel antimicrobial and antiparasitic agents CUBIST PHARMACEUTICALS, INC. (US) 1998-03-10 US claimed
WO-1997005132-A1 AMINOACYL ADENYLATE MIMICS AS NOVEL ANTIMICROBIAL AND ANTIPARASITIC AGENTS CUBIST PHARMACEUTICALS, INC. (US) 1997-02-13 WO claimed