SCHEMBL2274337

SCHEMBL2274337

COC[Si](C)(COC)c1ccccc1

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ESR1 P03372 1/20 0.37
ESR2 Q92731 1/20 0.37
CA4 P22748 2/20 0.35
MAPT P10636 2/20 0.33
TDP1 Q9NUW8 2/20 0.33
TSHR P16473 1/20 0.32
POLB P06746 4/20 0.32
CA2 P00918 2/20 0.31
LTA4H P09960 2/20 0.31
KCNH3 Q9ULD8 1/20 0.31
CA12 O43570 1/20 0.31
CA1 P00915 1/20 0.31
CA7 P43166 1/20 0.31
CA9 Q16790 1/20 0.31
CA14 Q9ULX7 1/20 0.31
RAB9A P51151 2/20 0.31
LMNA P02545 2/20 0.31
NPC1 O15118 1/20 0.31
NR1H2 P55055 1/20 0.31
NR1H3 Q13133 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL40410 0.81 MAPT (0.41) ESR1ESR2CA4MAPTPOLB
SCHEMBL2276981 0.80 CA4 (0.38) ESR1ESR2CA4MAPTTSHR
SCHEMBL8468944 0.77 ESR1 (0.34) ESR1ESR2MAPTTSHRPOLB
SCHEMBL29991977 0.74 LMNA (0.40) ESR1ESR2TDP1TSHRLTA4H
SCHEMBL2329848 0.72 NR1H2 (0.47) ESR1ESR2MAPTTSHRLMNA
SCHEMBL20583813 0.69 CA4 (0.33) ESR1ESR2CA4POLBCA2
SCHEMBL20637319 0.68 ESR1 (0.38) ESR1ESR2MAPTTSHRRAB9A
Hydrochloric Acid SCHEMBL10398554 0.68 MAPT (0.42) ESR1ESR2CA4MAPTTDP1
SCHEMBL8412870 0.68 CA4 (0.42) ESR1ESR2CA4MAPTTDP1
SCHEMBL2547799 0.68 MAPT (0.39) ESR1ESR2CA4MAPTNR1H2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 84 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115433296-B Catalyst composition and application thereof in olefin polymerization 中国科学院化学研究所 2024-04-05 CN claimed
CN-115433296-B Catalyst composition and application thereof in olefin polymerization 中国科学院化学研究所 2024-04-05 CN disclosed
CN-115433296-A Catalyst composition and application thereof in olefin polymerization 中国科学院化学研究所 2022-12-06 CN disclosed
CN-115433221-A Bis (alkoxyalkyl) silane external electron donor, preparation method thereof and application thereof in olefin polymerization 中国科学院化学研究所 2022-12-06 CN disclosed
US-20110196103-A1 PROPYLENE COPOLYMER, POLYPROPYLENE COMPOSITION AND USES THEREOF, TRANSITION METAL COMPOUND AND OLEFIN POLYMERIZATION CATALYST MITSUI CHEMICALS, INC. (US) 2011-08-11 US disclosed
US-7767313-B2 Polypropylene composite film comprising a metallocene-catalyzed propylene/1-butene random copolymer MITSUI CHEMICALS, INC. (JP) 2010-08-03 US disclosed
US-7737239-B2 Propylene copolymer, polypropylene composition and uses thereof, transition metal compound and olefin polymerization catalyst MITSUI CHEMICALS, INC. (JP) 2010-06-15 US disclosed
US-7728078-B2 Blend of a polypropylene and a elastomeric copolymer of 60-90 mol % propylene units and 10- 40 mol % of 1-butene units; sheets and films with excellent flexibility and impact resistance as well as sufficient heat resistance and low-temperature heat-sealability MITSUI CHEMICALS, INC. (JP) 2010-06-01 US disclosed
US-7678934-B2 Propylene copolymer, polypropylene composition and uses thereof, transition metal compound and olefin polymerization catalyst MITSUI CHEMICALS, INC. (JP) 2010-03-16 US disclosed
EP-1647575-B1 POLYPROPYLENE RESIN COMPOSITION PRIME POLYMER CO LTD (JP) 2009-07-29 EP disclosed
US-5595827-A BLEND WITH POLYTERPENE AND/OR PETROLEUM RESIN, MULTILAYER FILM FOR PACKAGING, WATER VAPOR BARRIER MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) 1997-01-21 US disclosed
EP-0634455-B1 Polypropylene resin composition and the use of the same MITSUI PETROCHEMICAL IND (JP) 1997-01-08 EP disclosed
US-5579913-A PACKAGING; WATERPROOFING, TRANSPARENT, HIGH MODULUS MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) 1996-12-03 US disclosed
EP-0683175-A2 Solid titanium catalyst component for olefin polymerization, process for preparation of the same, olefin polymerization catalyst and process for olefin polymerization MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) 1995-11-22 EP disclosed
EP-0669347-A1 Ethylene polymer, process for preparing the same, solid titanium catalyst component for ethylene polymerization and ethylene polymerization catalyst MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) 1995-08-30 EP disclosed
EP-0668296-A1 Ethylene polymer and process for preparing the same MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) 1995-08-23 EP disclosed
EP-0641807-A2 Olefin polymerization catalyst and process for preparing polypropylene and a propylene block copolymer MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) 1995-03-08 EP disclosed
EP-0634455-A1 Polypropylene resin composition and the use of the same MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) 1995-01-18 EP disclosed
EP-0585869-A1 Solid titanium catalyst component for olefin polymerization, process for preparing the same, catalyst for olefin polymerization and process for olefin polymerization MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) 1994-03-09 EP disclosed
EP-0452156-A2 Solid titanium catalyst component for olefin polymerization, olefin polymerization catalyst, prepolymerized polyolefin-containing catalyst and method of olefin polymerization MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) 1991-10-16 EP disclosed