SCHEMBL4041042

SCHEMBL4041042

N#CCC(Cc1c[nH]c2ccccc12)NC(=O)c1cc(I)ccc1OC(F)(F)F

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CTSL P07711 2/20 0.42
CTSS P25774 1/20 0.42
CTSK P43235 1/20 0.42
ITGB2 P05107 6/20 0.42
ICAM1 P05362 6/20 0.42
ITGAL P20701 6/20 0.42
ECE1 P42892 1/20 0.42
LMNA P02545 1/20 0.41
MAPT P10636 1/20 0.41
PTBP1 P26599 1/20 0.41
HTT P42858 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.41
TRPV1 Q8NER1 1/20 0.41
ACE P12821 1/20 0.41
CDK2 P24941 1/20 0.40
TACR1 P25103 1/20 0.40
HDAC3 O15379 1/20 0.40
HDAC4 P56524 1/20 0.40
HDAC1 Q13547 1/20 0.40
HDAC7 Q8WUI4 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3941599 0.90 ITGB2 (0.52) CTSLCTSSCTSKITGB2ICAM1
SCHEMBL13905561 0.87 ITGB2 (0.45) CTSLCTSSCTSKITGB2ICAM1
SCHEMBL13905574 0.87 HPGDS (0.44) CTSLCTSSCTSKITGB2ICAM1
SCHEMBL3944251 0.87 CTSL (0.45) CTSLCTSSCTSKITGB2ICAM1
SCHEMBL3943403 0.87 MAPT (0.41) CTSLCTSSCTSKITGB2ICAM1
SCHEMBL13905545 0.87 ITGB2 (0.45) CTSLITGB2ICAM1ITGALLMNA
SCHEMBL13905578 0.87 P2RY14 (0.43) CTSLCTSSCTSKITGB2ICAM1
SCHEMBL13905558 0.87 TACR1 (0.46) CTSLECE1LMNAMAPTPTBP1
SCHEMBL13905548 0.87 ITGB2 (0.44) CTSLCTSSCTSKITGB2ICAM1
SCHEMBL3948668 0.86 CTSL (0.43) CTSLCTSSCTSKITGB2ICAM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2044077-A1 DERIVATIVES AND ANALOGS OF N-ETHYLQUINOLONES AND N-ETHYLAZAQUINOLONES Glaxo Group Limited (GB) 2009-04-08 EP disclosed
EP-2019869-A1 FERMENTATIVE PRODUCTION OF LIPSTATIN KRKA (SI) 2009-02-04 EP disclosed
EP-2020404-A1 Cyanomethyl substituted N-Acyl Tryptamines Bayer Schering Pharma Aktiengesellschaft (DE) 2009-02-04 EP disclosed
EP-2016064-A2 METHODS FOR THE PREPARATION OF PYRAZOLE-CONTAINING COMPOUNDS Janssen Pharmaceutica, N.V. (BE) 2009-01-21 EP disclosed
WO-2008009700-A1 DERIVATIVES AND ANALOGS OF N-ETHYLQUINOLONES AND N-ETHYLAZAQUINOLONES GLAXO GROUP LIMITED (GB) 2008-01-24 WO disclosed
WO-2007134836-A1 FERMENTATIVE PRODUCTION OF LIPSTATIN KRKA (SI) 2007-11-29 WO disclosed
WO-2007131153-A2 METHODS FOR THE PREPARATION OF PYRAZOLE-CONTAINING COMPOUNDS JANSSEN PHARMACEUTICA N.V. (BE) 2007-11-15 WO disclosed