Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMYD3 | Q9H7B4 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | FAAH | O00519 | 4/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 4/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | IDH1 | O75874 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4037247 | 0.91 | ATM (0.38) | POLBFAAHRAB9AIDH1 | |
| SCHEMBL4039886 | 0.79 | POLB (0.47) | POLBRAB9ASMN1; SMN2MAPTKMT2A | |
| SCHEMBL4038652 | 0.77 | TSHR (0.43) | POLBRAB9ASMN1; SMN2MAPTKMT2A | |
| SCHEMBL4041338 | 0.77 | SMN1; SMN2 (0.41) | POLBRAB9ASMN1; SMN2MAPTKMT2A | |
| SCHEMBL4044962 | 0.77 | KMT2A (0.49) | SMN1; SMN2MAPTKMT2ATSHRTDP1 | |
| SCHEMBL4037383 | 0.76 | KMT2A (0.41) | POLBRAB9ASMN1; SMN2KMT2ATSHR | |
| SCHEMBL4039067 | 0.76 | NPC1 (0.44) | POLBRAB9ASMN1; SMN2KMT2ATSHR | |
| SCHEMBL4044939 | 0.76 | NPC1 (0.46) | POLBRAB9ASMN1; SMN2MAPTKMT2A | |
| SCHEMBL4037171 | 0.76 | NPC1 (0.47) | RAB9ASMN1; SMN2KMT2ATSHR | |
| SCHEMBL4042940 | 0.76 | TSHR (0.45) | POLBRAB9ASMN1; SMN2KMT2ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2038259-A1 | BENZIMIDAZOLE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, THEIR USE AS FXR AGONISTS AND PHARMACEUTICAL PREPARATIONS CONTAINING THE SAME | F.HOFFMANN-LA ROCHE AG (CH) | 2009-03-25 | — | — | EP | disclosed |
| WO-2008000643-A1 | BENZIMIDAZOLE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, THEIR USE AS FXR AGONISTS AND PHARMACEUTICAL PREPARATIONS CONTAINING THE SAME | F. HOFFMANN-LA ROCHE AG (CH) | 2008-01-03 | — | — | WO | disclosed |