Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | DAO | P14920 | 1/20 | 0.41 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.36 |
| ▸ | NR3C1 | P04150 | 13/20 | 0.36 |
| ▸ | NR3C2 | P08235 | 8/20 | 0.36 |
| ▸ | PGR | P06401 | 6/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | SNCA | P37840 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | MASP2 | O00187 | 1/20 | 0.33 |
| ▸ | KDM5A | P29375 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4269626 | 0.79 | DAO (0.50) | KDM4ESMN1; SMN2DAOHRH4NR3C1 | |
| SCHEMBL4271962 | 0.77 | DAO (0.47) | KDM4ESMN1; SMN2DAOHRH4NR3C1 | |
| SCHEMBL4271774 | 0.76 | DAO (0.44) | KDM4ESMN1; SMN2DAOHRH4NR3C1 | |
| SCHEMBL3357467 | 0.76 | DAO (0.49) | KDM4ESMN1; SMN2DAOHRH4NR3C1 | |
| SCHEMBL29856283 | 0.76 | DAO (0.49) | KDM4ESMN1; SMN2DAOHRH4NR3C1 | |
| SCHEMBL13656963 | 0.73 | DAO (0.46) | KDM4ESMN1; SMN2DAOHRH4NR3C1 | |
| Hydrochloric Acid SCHEMBL4271746 | 0.72 | DAO (0.45) | KDM4EDAOHRH4NR3C1NR3C2 | |
| SCHEMBL23934135 | 0.71 | DAO (0.42) | SMN1; SMN2DAOHRH4NR3C1NR3C2 | |
| SCHEMBL24645390 | 0.71 | DAO (0.42) | KDM4ESMN1; SMN2DAOHRH4NR3C1 | |
| SCHEMBL4270694 | 0.70 | SLC6A2 (0.46) | DAONR3C1NR3C2PGRMASP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2051710-A2 | COMPOSITIONS AND METHODS FOR TREATING, REDUCING, AMELIORATING, OR ALLEVIATING POSTERIOR-SEGMENT OPHTHALMIC DISEASES | Bausch & Lomb Incorporated (US) | 2009-04-29 | — | — | EP | disclosed |
| WO-2008021729-A2 | COMPOSITIONS AND METHODS FOR TREATING, REDUCING, AMELIORATING, OR ALLEVIATING POSTERIOR-SEGMENT OPHTHALMIC DISEASES | BAUSCH & LOMB INCORPORATED (US) | 2008-02-21 | — | — | WO | disclosed |