Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 16/20 | 0.50 |
| ▸ | CTSD | P07339 | 4/20 | 0.50 |
| ▸ | BCHE | P06276 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4036954 | 0.94 | BACE1 (0.46) | BACE1CTSDBCHE | |
| SCHEMBL3939381 | 0.89 | BCHE (0.47) | BACE1CTSDBCHE | |
| SCHEMBL3348652 | 0.83 | BACE1 (0.41) | BACE1CTSD | |
| SCHEMBL3355569 | 0.80 | BACE1 (0.42) | BACE1CTSD | |
| SCHEMBL3351919 | 0.80 | BACE1 (0.46) | BACE1CTSD | |
| SCHEMBL6647479 | 0.80 | BACE1 (0.46) | BACE1CTSD | |
| SCHEMBL7051773 | 0.77 | BACE1 (0.49) | BACE1CTSD | |
| SCHEMBL4043818 | 0.71 | BCHE (0.41) | BACE1BCHE | |
| SCHEMBL4045031 | 0.71 | KDM1A (0.46) | BACE1CTSDBCHE | |
| SCHEMBL7048932 | 0.70 | DNM1 (0.48) | BACE1BCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2051710-A2 | COMPOSITIONS AND METHODS FOR TREATING, REDUCING, AMELIORATING, OR ALLEVIATING POSTERIOR-SEGMENT OPHTHALMIC DISEASES | Bausch & Lomb Incorporated (US) | 2009-04-29 | — | — | EP | disclosed |
| WO-2008021729-A2 | COMPOSITIONS AND METHODS FOR TREATING, REDUCING, AMELIORATING, OR ALLEVIATING POSTERIOR-SEGMENT OPHTHALMIC DISEASES | BAUSCH & LOMB INCORPORATED (US) | 2008-02-21 | — | — | WO | disclosed |
| EP-1651592-A2 | NOVEL DIBENZO[B,F]OXEPINE-10-CARBOXAMIDES AND PHARMACEUTICAL USES THEREOF | Novartis AG (CH) | 2006-05-03 | — | — | EP | disclosed |
| WO-2005014517-A2 | NOVEL DIBENZO[B,F]OXEPINE-10-CARBOXAMIDES AND PHARMACEUTICAL USES THEREOF | NOVARTIS AG (CH) | 2005-02-17 | — | — | WO | disclosed |