Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | C3AR1 | Q16581 | 1/20 | 0.46 |
| ▸ | CNR2 | P34972 | 4/20 | 0.41 |
| ▸ | CNR1 | P21554 | 3/20 | 0.41 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.40 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4040357 | 0.86 | ALDH1A1 (0.41) | C3AR1CNR2CNR1MEN1KMT2A | |
| SCHEMBL4038768 | 0.86 | ALDH1A1 (0.41) | C3AR1CNR2CNR1MEN1KMT2A | |
| SCHEMBL4039869 | 0.83 | HPGD (0.45) | LMNAMEN1KMT2AALDH1A1NPSR1 | |
| SCHEMBL4036317 | 0.82 | HPGD (0.43) | C3AR1MEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL4037895 | 0.81 | HPGD (0.43) | CNR2CNR1LMNAMEN1KMT2A | |
| SCHEMBL4034357 | 0.81 | HPGD (0.43) | CNR2CNR1LMNAMEN1KMT2A | |
| SCHEMBL4035291 | 0.80 | EGFR (0.42) | LMNAMEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL4036690 | 0.80 | TSHR (0.43) | LMNAMEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL4044158 | 0.80 | GAA (0.47) | LMNAMEN1KMT2AALDH1A1GAA | |
| SCHEMBL4039455 | 0.80 | KMT2A (0.48) | C3AR1LMNAMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2038259-A1 | BENZIMIDAZOLE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, THEIR USE AS FXR AGONISTS AND PHARMACEUTICAL PREPARATIONS CONTAINING THE SAME | F.HOFFMANN-LA ROCHE AG (CH) | 2009-03-25 | — | — | EP | disclosed |
| WO-2008000643-A1 | BENZIMIDAZOLE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, THEIR USE AS FXR AGONISTS AND PHARMACEUTICAL PREPARATIONS CONTAINING THE SAME | F. HOFFMANN-LA ROCHE AG (CH) | 2008-01-03 | — | — | WO | disclosed |