Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 5/20 | 0.37 |
| ▸ | HTT | P42858 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | SCN4A | P35499 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | BCL9 | O00512 | 1/20 | 0.35 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3881328 | 0.75 | L3MBTL1 (0.74) | L3MBTL1MAPTHTTPOLBMAPK1 | |
| SCHEMBL4266168 | 0.69 | MAPT (0.48) | L3MBTL1MEN1KMT2ASMN1; SMN2MAPT | |
| SCHEMBL26758110 | 0.69 | L3MBTL1 (0.56) | L3MBTL1MEN1KMT2ASMN1; SMN2MAPT | |
| SCHEMBL28590881 | 0.68 | USP5 (0.61) | L3MBTL1MEN1KMT2AMAPTHTT | |
| SCHEMBL28608341 | 0.68 | L3MBTL1 (0.57) | L3MBTL1MEN1KMT2AMAPTHTT | |
| SCHEMBL26758106 | 0.66 | L3MBTL1 (0.58) | L3MBTL1MEN1KMT2ASMN1; SMN2MAPT | |
| SCHEMBL28581747 | 0.65 | L3MBTL1 (0.56) | L3MBTL1MEN1KMT2ASMN1; SMN2MAPT | |
| SCHEMBL9800651 | 0.65 | HTT (0.49) | L3MBTL1MEN1KMT2AMAPTHTT | |
| SCHEMBL4252776 | 0.64 | PARP1 (0.72) | L3MBTL1MEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL30656820 | 0.64 | L3MBTL1 (0.68) | L3MBTL1MEN1KMT2ASMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2010504-A1 | QUINAZOLIN-4-ONE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | AstraZeneca AB (SE) | 2009-01-07 | — | — | EP | disclosed |
| WO-2007119055-A1 | QUINAZOLIN-4-ONE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ASTRAZENECA AB (SE) | 2007-10-25 | — | — | WO | disclosed |