Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 7/20 | 0.72 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.51 |
| ▸ | NAMPT | P43490 | 1/20 | 0.51 |
| ▸ | XDH | P47989 | 1/20 | 0.51 |
| ▸ | IP6K1 | Q92551 | 5/20 | 0.51 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.48 |
| ▸ | PIM1 | P11309 | 1/20 | 0.48 |
| ▸ | AKT1 | P31749 | 1/20 | 0.48 |
| ▸ | FLT3 | P36888 | 1/20 | 0.48 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.44 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.44 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.44 |
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.43 |
| ▸ | TTBK2 | Q6IQ55 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL158065 | 0.84 | PARP1 (1.00) | PARP1CYP3A4NAMPTXDHIP6K1 | |
| SCHEMBL9541519 | 0.82 | IP6K1 (0.68) | PARP1IP6K1CHEK1PIM1AKT1 | |
| SCHEMBL4252782 | 0.81 | PARP1 (0.69) | PARP1IP6K1CHEK1PIM1AKT1 | |
| SCHEMBL27174587 | 0.78 | PARP1 (0.50) | PARP1IP6K1CHEK1PIM1AKT1 | |
| SCHEMBL29539395 | 0.78 | PARP1 (0.50) | PARP1IP6K1CHEK1PIM1AKT1 | |
| SCHEMBL1438865 | 0.76 | PARP1 (0.77) | PARP1CYP3A4NAMPTXDHIP6K1 | |
| SCHEMBL31000787 | 0.76 | PARP1 (0.77) | PARP1CYP3A4NAMPTXDHIP6K1 | |
| SCHEMBL9800651 | 0.75 | HTT (0.49) | CYP3A4ALDH1A1HSPB1MEN1MAPT | |
| SCHEMBL3881328 | 0.74 | L3MBTL1 (0.74) | IP6K1ALDH1A1HSPB1MAPTL3MBTL1 | |
| SCHEMBL1257333 | 0.74 | PARP1 (0.63) | PARP1IP6K1CHEK1PIM1AKT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090149484-A1 | QUINAZOLIN-4-ONE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ASTRAZENECA AB (SE) | 2009-06-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090149484-A1 | QUINAZOLIN-4-ONE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | BRAF, RAF1, NRAS | PARP1 1026/4885CYP3A4 373/4885NAMPT 1315/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.