Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 2/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | FYN | P06241 | 1/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.43 |
| ▸ | SRC | P12931 | 1/20 | 0.43 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.43 |
| ▸ | FLT1 | P17948 | 1/20 | 0.43 |
| ▸ | FLT4 | P35916 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.43 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.43 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.43 |
| ▸ | GSK3A | P49840 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | CDK7 | P50613 | 1/20 | 0.43 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.43 |
| ▸ | CSNK1G1 | Q9HCP0 | 1/20 | 0.43 |
| ▸ | BRAF | P15056 | 2/20 | 0.39 |
| ▸ | RAF1 | P04049 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4040115 | 0.82 | LCK (0.48) | LCKABL1FYNPDGFRBFGFR1 | |
| SCHEMBL4042440 | 0.80 | LCK (0.46) | LCKABL1FYNPDGFRBFGFR1 | |
| SCHEMBL4050586 | 0.78 | LCK (0.45) | LCKABL1FYNPDGFRBFGFR1 | |
| SCHEMBL4043150 | 0.77 | PDGFRB (0.57) | LCKABL1FYNPDGFRBFGFR1 | |
| SCHEMBL4047952 | 0.75 | PDGFRB (0.57) | LCKABL1FYNPDGFRBFGFR1 | |
| SCHEMBL4046330 | 0.73 | LCK (0.37) | LCKABL1FYNPDGFRBFGFR1 | |
| SCHEMBL4044788 | 0.73 | FBP1 (0.47) | LCKABL1FYNPDGFRBFGFR1 | |
| SCHEMBL4041829 | 0.72 | FADS1 (0.42) | LCKABL1FYNPDGFRBFGFR1 | |
| SCHEMBL4041188 | 0.70 | KDR (0.35) | LCKABL1FYNPDGFRBFGFR1 | |
| SCHEMBL4045373 | 0.70 | PDGFRB (0.47) | ABL1PDGFRBSRCKDREGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1689720-B1 | PYRAZOLYL DERIVATIVES IN THE FORM OF DRUGS FOR TREATING ACUTE OR CHRONIC NEURONAL REGRESSIONS | AVENTIS PHARMA SA (FR) | 2009-04-15 | — | — | EP | disclosed |