Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LY6K | Q17RY6 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 2/20 | 0.52 |
| ▸ | FLT1 | P17948 | 2/20 | 0.48 |
| ▸ | FLT4 | P35916 | 2/20 | 0.48 |
| ▸ | KDR | P35968 | 2/20 | 0.48 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.47 |
| ▸ | F2 | P00734 | 1/20 | 0.47 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.47 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.47 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.47 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.47 |
| ▸ | NOXO1 | Q8NFA2 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 3/20 | 0.45 |
| ▸ | ITK | Q08881 | 2/20 | 0.45 |
| ▸ | NSD2 | O96028 | 1/20 | 0.44 |
| ▸ | NSD3 | Q9BZ95 | 1/20 | 0.44 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.43 |
| ▸ | GBA1 | P04062 | 1/20 | 0.43 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5819089 | 0.89 | FLT1 (0.53) | LY6KPKMFLT1FLT4KDR | |
| SCHEMBL4039166 | 0.76 | PDGFRB (0.53) | FLT1FLT4KDR | |
| SCHEMBL14253689 | 0.75 | PKM (0.74) | PKML3MBTL3F2PRSS1PRSS2 | |
| SCHEMBL20533126 | 0.75 | FOLH1 (0.66) | LY6KPKMFLT1FLT4KDR | |
| SCHEMBL19326754 | 0.74 | PKM (0.60) | LY6KPKMFLT1FLT4KDR | |
| SCHEMBL13528559 | 0.74 | PKM (0.60) | LY6KPKML3MBTL3F2PRSS1 | |
| SCHEMBL18736370 | 0.74 | PKM (0.52) | LY6KPKMF2PRSS1PRSS2 | |
| SCHEMBL19326743 | 0.74 | FOLH1 (0.58) | LY6KPKML3MBTL3F2PRSS1 | |
| SCHEMBL12319337 | 0.74 | PKM (0.57) | LY6KPKML3MBTL3F2PRSS1 | |
| SCHEMBL13528032 | 0.74 | L3MBTL3 (0.56) | LY6KPKML3MBTL3F2PRSS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1506175-B1 | N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDGF RECEPTOR INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2009-04-01 | — | — | EP | disclosed |