Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 6/20 | 0.65 |
| ▸ | HTR2A | P28223 | 5/20 | 0.65 |
| ▸ | KMO | O15229 | 2/20 | 0.53 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.46 |
| ▸ | OXER1 | Q8TDS5 | 1/20 | 0.46 |
| ▸ | ACLY | P53396 | 2/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.42 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.42 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.42 |
| ▸ | GRIK5 | Q16478 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4042962 | 1.00 | HTR2C (0.65) | HTR2CHTR2AKMOPRMT5OXER1 | |
| SCHEMBL3951049 | 0.84 | HTR2C (0.63) | HTR2CHTR2APRMT5ACLYHDAC3 | |
| SCHEMBL3951044 | 0.84 | HTR2C (0.63) | HTR2CHTR2APRMT5ACLYHDAC3 | |
| SCHEMBL11032483 | 0.83 | HTR2C (0.65) | HTR2CHTR2APRMT5HDAC3HDAC1 | |
| SCHEMBL11033586 | 0.81 | HTR2C (0.68) | HTR2CHTR2APRMT5HDAC8HDAC6 | |
| Fumaric Acid SCHEMBL7091387 | 0.80 | HTR2C (0.78) | HTR2CHTR2APRMT5OXER1ACLY | |
| Fumaric Acid SCHEMBL7091385 | 0.80 | HTR2C (0.78) | HTR2CHTR2APRMT5OXER1ACLY | |
| SCHEMBL8959591 | 0.79 | HTR2C (1.00) | HTR2CHTR2APRMT5 | |
| SCHEMBL7092716 | 0.79 | HTR2C (1.00) | HTR2CHTR2APRMT5 | |
| SCHEMBL2700471 | 0.79 | KMT2A (0.58) | HDAC1HDAC2HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2033962-A1 | Tetracyclic indolopyridines as EG5 inhibitors | 4SC AG (DE) | 2009-03-11 | — | — | EP | disclosed |
| WO-2009024613-A1 | TETRACYCLIC INDOLOPYRIDINES AS EG5 INHIBITORS | 4SC AG (DE) | 2009-02-26 | — | — | WO | disclosed |
| US-4448785-A | N-Unsaturated fatty acid amides of tryptophan ester homologues and anti-cholesteric use thereof | SANDOZ, INC. (US) | 1984-05-15 | — | — | US | disclosed |