Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 3/20 | 0.47 |
| ▸ | DPP4 | P27487 | 2/20 | 0.42 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.42 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.42 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5941514 | 0.83 | CTSK (0.64) | CTSKDPP4DPP8DPP9DPP7 | |
| SCHEMBL4048380 | 0.83 | CTSK (0.64) | CTSKDPP4DPP8DPP9DPP7 | |
| SCHEMBL4042281 | 0.83 | CTSK (0.44) | CTSKDPP4DPP8DPP9DPP7 | |
| SCHEMBL4049054 | 0.82 | DPP4 (0.52) | CTSKDPP4DPP8DPP9DPP7 | |
| SCHEMBL4044250 | 0.82 | CTSK (0.49) | CTSKDPP4DPP8DPP9DPP7 | |
| SCHEMBL4044700 | 0.82 | CTSK (0.52) | CTSKDPP4DPP8DPP9DPP7 | |
| SCHEMBL4043810 | 0.81 | CTSK (0.64) | CTSK | |
| SCHEMBL4044858 | 0.80 | CTSK (0.57) | CTSK | |
| SCHEMBL4040770 | 0.79 | CTSK (0.48) | CTSKDPP4DPP8DPP9DPP7 | |
| SCHEMBL4046498 | 0.79 | CTSK (0.78) | CTSKLMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546150-B1 | PYRROLE DERIVATIVES AS INHIBITORS OF CYTEINE PROTEASES | AMURA THERAPEUTICS LTD (GB) | 2009-03-04 | — | — | EP | claimed |