Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 4/20 | 0.52 |
| ▸ | DPP8 | Q6V1X1 | 3/20 | 0.41 |
| ▸ | DPP4 | P27487 | 3/20 | 0.41 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.41 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.41 |
| ▸ | CTSS | P25774 | 1/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.36 |
| ▸ | PREP | P48147 | 2/20 | 0.36 |
| ▸ | FAP | Q12884 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4048380 | 0.89 | CTSK (0.64) | CTSKDPP8DPP4DPP9DPP7 | |
| SCHEMBL5941514 | 0.89 | CTSK (0.64) | CTSKDPP8DPP4DPP9DPP7 | |
| SCHEMBL5942111 | 0.88 | CTSK (0.51) | CTSKDPP8DPP4DPP9DPP7 | |
| SCHEMBL4050765 | 0.88 | CTSK (0.51) | CTSKDPP8DPP4DPP9DPP7 | |
| SCHEMBL4049054 | 0.84 | DPP4 (0.52) | CTSKDPP8DPP4DPP9DPP7 | |
| SCHEMBL4044250 | 0.84 | CTSK (0.49) | CTSKDPP8DPP4DPP9DPP7 | |
| SCHEMBL4040770 | 0.83 | CTSK (0.48) | CTSKDPP8DPP4DPP9DPP7 | |
| SCHEMBL4045680 | 0.82 | DPP4 (0.41) | CTSKDPP8DPP4DPP9DPP7 | |
| SCHEMBL4042997 | 0.82 | CTSK (0.47) | CTSKDPP8DPP4DPP9DPP7 | |
| SCHEMBL4041700 | 0.81 | CTSK (0.69) | CTSKDPP8DPP9CTSSPREP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546150-B1 | PYRROLE DERIVATIVES AS INHIBITORS OF CYTEINE PROTEASES | AMURA THERAPEUTICS LTD (GB) | 2009-03-04 | — | — | EP | claimed |