Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | THRB | P10828 | 2/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20302484 | 0.79 | CYP1A2 (0.47) | ALDH1A1CASP1MAPTNPSR1CYP1A2 | |
| SCHEMBL13912896 | 0.77 | ALDH1A1 (0.39) | ALDH1A1POLBMAPK1SMN1; SMN2TP53 | |
| SCHEMBL13912895 | 0.77 | ALDH1A1 (0.39) | ALDH1A1POLBMAPK1SMN1; SMN2TP53 | |
| SCHEMBL4041010 | 0.75 | ALDH1A1 (0.45) | ALDH1A1POLBMAPK1SMN1; SMN2TP53 | |
| SCHEMBL13912894 | 0.75 | KMT2A (0.40) | ALDH1A1POLBMAPK1SMN1; SMN2TP53 | |
| SCHEMBL4112444 | 0.75 | ALDH1A1 (0.38) | ALDH1A1POLBMAPK1SMN1; SMN2TP53 | |
| SCHEMBL4119187 | 0.75 | ALDH1A1 (0.38) | ALDH1A1POLBMAPK1SMN1; SMN2TP53 | |
| SCHEMBL4121707 | 0.74 | ALDH1A1 (0.37) | ALDH1A1POLBMAPK1SMN1; SMN2TP53 | |
| SCHEMBL4102069 | 0.74 | KMT2A (0.39) | ALDH1A1POLBMAPK1SMN1; SMN2TP53 | |
| SCHEMBL1179166 | 0.74 | CYP1A2 (0.54) | ALDH1A1POLBMAPK1SMN1; SMN2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090069334-A1 | Pyridazine based alpha-helix mimetics | THE SCRIPPS RESEARCH INSTITUTE (US) | 2009-03-12 | — | — | US | disclosed |
| US-20090069334-A1 | Pyridazine based alpha-helix mimetics | THE SCRIPPS RESEARCH INSTITUTE (US) | 2009-03-12 | — | — | US | disclosed |
| WO-2009025751-A1 | PYRIDAZINE BASED ALPHA-HELIX MIMETICS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2009-02-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090069334-A1 | Pyridazine based alpha-helix mimetics | H1-4, H1-5, H1-0 | ALDH1A1 3022/4885POLB 631/4885MAPK1 2985/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.