Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | GABRP | O00591 | 1/20 | 0.33 |
| ▸ | GABRD | O14764 | 1/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.33 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.33 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.33 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.33 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4102069 | 0.77 | KMT2A (0.39) | ALDH1A1SMN1; SMN2POLBMAPK1MEN1 | |
| SCHEMBL4043097 | 0.74 | ALDH1A1 (0.44) | ALDH1A1SMN1; SMN2POLBMAPK1MEN1 | |
| SCHEMBL13912894 | 0.74 | KMT2A (0.40) | ALDH1A1SMN1; SMN2POLBMAPK1MEN1 | |
| SCHEMBL13902658 | 0.70 | — | — | |
| SCHEMBL4046561 | 0.70 | SMN1; SMN2 (0.39) | ALDH1A1SMN1; SMN2POLBKMT2ALMNA | |
| SCHEMBL4115884 | 0.69 | — | — | |
| SCHEMBL4112444 | 0.69 | ALDH1A1 (0.38) | ALDH1A1SMN1; SMN2POLBMAPK1MEN1 | |
| SCHEMBL13912895 | 0.68 | ALDH1A1 (0.39) | ALDH1A1SMN1; SMN2POLBMAPK1MEN1 | |
| SCHEMBL13912896 | 0.68 | ALDH1A1 (0.39) | ALDH1A1SMN1; SMN2POLBMAPK1MEN1 | |
| SCHEMBL4121710 | 0.68 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090069334-A1 | Pyridazine based alpha-helix mimetics | THE SCRIPPS RESEARCH INSTITUTE (US) | 2009-03-12 | — | — | US | disclosed |
| US-20090069334-A1 | Pyridazine based alpha-helix mimetics | THE SCRIPPS RESEARCH INSTITUTE (US) | 2009-03-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090069334-A1 | Pyridazine based alpha-helix mimetics | H1-4, H1-5, H1-0 | ALDH1A1 3022/4885SMN1; SMN2 4121/4885POLB 631/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.