Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 2/20 | 0.79 |
| ▸ | ATR | Q13535 | 15/20 | 0.59 |
| ▸ | MET | P08581 | 2/20 | 0.53 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.52 |
| ▸ | KDR | P35968 | 1/20 | 0.52 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.52 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.52 |
| ▸ | MTOR | P42345 | 1/20 | 0.52 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.52 |
| ▸ | PRKDC | P78527 | 1/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3950078 | 0.89 | EGFR (0.72) | EGFRATRPIK3CDKDRPIK3CA | |
| SCHEMBL4040666 | 0.89 | EGFR (1.00) | EGFRATRPRKDCATM | |
| SCHEMBL4038019 | 0.85 | EGFR (0.80) | EGFRATRMETPRKDCATM | |
| SCHEMBL4213635 | 0.80 | EGFR (0.71) | EGFRATRPRKDCATM | |
| SCHEMBL4037269 | 0.80 | EGFR (0.73) | EGFRATRPRKDCATM | |
| SCHEMBL4045565 | 0.78 | EGFR (0.58) | EGFRATRMETKDR | |
| SCHEMBL4041430 | 0.78 | EGFR (0.80) | EGFRATR | |
| SCHEMBL4041919 | 0.78 | EGFR (0.79) | EGFRATR | |
| SCHEMBL4047011 | 0.77 | EGFR (0.56) | EGFRATRMETPIK3CDKDR | |
| SCHEMBL4044231 | 0.77 | EGFR (0.78) | EGFRATRMET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009024825-A1 | 2-PYRAZINYLBENZIMIDAZOLE DERIVATIVES AS RECEPTOR TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2009-02-26 | — | — | WO | disclosed |
| WO-2009024825-A1 | 2-PYRAZINYLBENZIMIDAZOLE DERIVATIVES AS RECEPTOR TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2009-02-26 | — | — | WO | disclosed |