Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.58 |
| ▸ | ATR | Q13535 | 13/20 | 0.51 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.49 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.49 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.49 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.49 |
| ▸ | KDR | P35968 | 2/20 | 0.49 |
| ▸ | FLT3 | P36888 | 2/20 | 0.49 |
| ▸ | MET | P08581 | 1/20 | 0.46 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.46 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3950078 | 0.90 | EGFR (0.72) | EGFRATRFGFR1FGFR2FGFR4 | |
| SCHEMBL4045787 | 0.85 | EGFR (0.78) | EGFRATRFGFR1FGFR2FGFR3 | |
| SCHEMBL2383486 | 0.84 | MET (0.58) | FGFR1FGFR2FGFR4FGFR3KDR | |
| SCHEMBL4047011 | 0.83 | EGFR (0.56) | EGFRATRFGFR1FGFR2FGFR4 | |
| SCHEMBL4047605 | 0.82 | EGFR (0.62) | EGFRATRFGFR1FGFR2FGFR3 | |
| SCHEMBL4046506 | 0.80 | EGFR (0.53) | EGFRATRFGFR1FGFR2FGFR4 | |
| SCHEMBL4044910 | 0.80 | EGFR (0.53) | EGFRATRFGFR1FGFR2FGFR4 | |
| SCHEMBL2681566 | 0.79 | MET (0.58) | EGFRMETTNK2 | |
| SCHEMBL4044231 | 0.79 | EGFR (0.78) | EGFRATRFGFR1FGFR2FGFR3 | |
| SCHEMBL4043236 | 0.78 | EGFR (0.79) | EGFRATRKDRMET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009024825-A1 | 2-PYRAZINYLBENZIMIDAZOLE DERIVATIVES AS RECEPTOR TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2009-02-26 | — | — | WO | disclosed |