Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATR | Q13535 | 18/20 | 0.78 |
| ▸ | CDK1 | P06493 | 1/20 | 0.45 |
| ▸ | CDK2 | P24941 | 1/20 | 0.45 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.45 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.45 |
| ▸ | KARS1 | Q15046 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3058004 | 0.88 | ATR (1.00) | ATRCDK1CDK2MKNK1MKNK2 | |
| SCHEMBL4008991 | 0.78 | ATR (0.60) | ATRCDK1CDK2MKNK1MKNK2 | |
| SCHEMBL4039257 | 0.76 | ATR (0.80) | ATR | |
| SCHEMBL4042032 | 0.76 | EGFR (0.62) | ATR | |
| SCHEMBL4041097 | 0.74 | EGFR (0.47) | ATR | |
| SCHEMBL4011663 | 0.74 | ATR (0.75) | ATRCDK1CDK2MKNK1MKNK2 | |
| SCHEMBL4009550 | 0.72 | ATR (0.72) | ATR | |
| SCHEMBL4555462 | 0.71 | ATR (0.81) | ATR | |
| SCHEMBL4045589 | 0.71 | EGFR (0.56) | ATR | |
| SCHEMBL3051743 | 0.71 | ATR (1.00) | ATR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009024825-A1 | 2-PYRAZINYLBENZIMIDAZOLE DERIVATIVES AS RECEPTOR TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2009-02-26 | — | — | WO | disclosed |