Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 5/20 | 0.48 |
| ▸ | HPGDS | O60760 | 2/20 | 0.42 |
| ▸ | CTSS | P25774 | 2/20 | 0.40 |
| ▸ | CTSB | P07858 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.40 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.40 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | CHRNA7 | P36544 | 5/20 | 0.38 |
| ▸ | HTR3E | A5X5Y0 | 4/20 | 0.38 |
| ▸ | HTR3B | O95264 | 4/20 | 0.38 |
| ▸ | HTR3A | P46098 | 4/20 | 0.38 |
| ▸ | HTR3D | Q70Z44 | 4/20 | 0.38 |
| ▸ | HTR3C | Q8WXA8 | 4/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | F10 | P00742 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4051356 | 0.92 | CTSK (0.48) | CTSKHPGDSCTSSCTSBCHRNA7 | |
| SCHEMBL4044971 | 0.88 | CTSK (0.50) | CTSKHPGDSCTSSCTSBCHRNA7 | |
| SCHEMBL4043168 | 0.88 | CTSK (0.48) | CTSKHPGDSCTSSCTSBCHRNA7 | |
| SCHEMBL4043996 | 0.88 | CTSK (0.55) | CTSKHPGDSCTSSCTSBNPC1 | |
| SCHEMBL4041020 | 0.86 | CTSK (0.54) | CTSKHPGDSCTSSCTSB | |
| SCHEMBL4043955 | 0.85 | CTSK (0.58) | CTSKCTSSCTSB | |
| SCHEMBL4040699 | 0.83 | CTSK (0.55) | CTSKHPGDSCTSSCTSBCHRNA7 | |
| SCHEMBL4045241 | 0.83 | CTSK (0.55) | CTSKHPGDSCTSSCTSBNPC1 | |
| SCHEMBL4042777 | 0.83 | CTSK (0.57) | CTSKHPGDSCTSSCTSBNPC1 | |
| SCHEMBL4042238 | 0.83 | CTSK (0.70) | CTSKCTSSCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546150-B1 | PYRROLE DERIVATIVES AS INHIBITORS OF CYTEINE PROTEASES | AMURA THERAPEUTICS LTD (GB) | 2009-03-04 | — | — | EP | claimed |