Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 2/20 | 0.41 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | CTSK | P43235 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4038417 | 0.88 | NR1H2 (0.38) | NR1H2LIPGMAPTKCNH2 | |
| SCHEMBL4047164 | 0.80 | CSNK1E (0.41) | NR1H2MAPTGPR119ALDH1A1MAPK1 | |
| SCHEMBL4036501 | 0.75 | USP2 (0.41) | NR1H2MAPTGPR119USP2SMN1; SMN2 | |
| SCHEMBL4039181 | 0.74 | CSNK1E (0.39) | NR1H2MAPTGPR119USP2SMN1; SMN2 | |
| SCHEMBL14841535 | 0.74 | KCNH2 (0.39) | NR1H2MAPTKCNH2GPR119ALDH1A1 | |
| SCHEMBL4041480 | 0.74 | GBA1 (0.49) | NR1H2MAPTGPR119ALDH1A1MAPK1 | |
| SCHEMBL4038918 | 0.72 | SQOR (0.44) | NR1H2MAPTGPR119MAPK1 | |
| SCHEMBL4042990 | 0.72 | GPR119 (0.42) | NR1H2GPR119 | |
| SCHEMBL4039021 | 0.72 | MEN1 (0.41) | NR1H2MAPTKCNH2GPR119ESR2 | |
| SCHEMBL4041240 | 0.72 | NR1H2 (0.44) | NR1H2MAPTGPR119ESR2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 86 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101466727-B | HCV/HIV inhibitors and uses thereof | NOVARTIS AG | 2012-10-17 | — | — | CN | claimed |
| CN-101160301-B | Aminoalkyl-amidomethyl-substituted 2- (4-sulfonylamino) -3-hydroxy-3, 4-dihydro-2H-chromen-6-yl derivatives and their use as potassium channel blockers | SOLVAY PHARM BV | 2012-03-28 | — | — | CN | claimed |
| CN-1596106-B | Use of trifluoroacetyl alkyl-substituted phenyl derivatives, phenol derivatives, and benzoyl derivatives in the treatment and/or prophylaxis of obesity and complications and/or sequelas | SOLVAY PHARM BV | 2011-05-11 | — | — | CN | claimed |
| CN-101981028-A | Substituted piperidines as renin inhibitors | NOVARTIS AG | 2011-02-23 | — | — | CN | claimed |
| CN-101939318-A | Substituted piperidines as renin inhibitors | NOVARTIS AG | 2011-01-05 | — | — | CN | claimed |
| CN-101687875-A | Pyrrolopyrimidin-7-one derivatives and their use as pharmaceuticals | ASTRAZENECA AB | 2010-03-31 | — | — | CN | claimed |
| CN-101663284-A | Macrocyclic compounds as hcv ns3 protease inhibitors | NOVARTIS AG | 2010-03-03 | — | — | CN | claimed |
| CN-101541826-A | Macrocyclic HCV inhibitors and their uses | NOVARTIS AG (CH) | 2009-09-23 | — | — | CN | claimed |
| CN-100506815-C | Piperidinyl targeting compounds that selectively bind integrins | JANSSEN PHARMACEUTICA NV (BE) | 2009-07-01 | — | — | CN | claimed |
| CN-101466728-A | HCV inhibitors comprising beta amino acids and their uses | NOVARTIS AG (CH) | 2009-06-24 | — | — | CN | claimed |
| CN-1900080-A | Inhibitors of cruzipain and other cysteine proteases | AMURA THERAPEUTICS LTD (GB) | 2007-01-24 | — | — | CN | claimed |
| CN-1856501-A | Amidomethyl substituted 1-(carboxyalkyl)-cyclopentylcarbonylamino-benzazepine-N-acetic acid derivatives, process and intermediate products for their preparation and medicaments containing these compou | SOLVAY PHARM GMBH (DE) | 2006-11-01 | — | — | CN | claimed |
| CN-1269822-C | Inhibitors of kruenza protease and other cysteine proteases | AMURA THERAPEUTICS LTD (GB) | 2006-08-16 | — | — | CN | claimed |
| CN-1688572-A | Piperidinyl targeting compounds that selectively bind integrins | JANSSEN PHARMACEUTICA NV (BE) | 2005-10-26 | — | — | CN | claimed |
| CN-1681817-A | Biologically active compounds | AMURA THERAPEUTICS LTD (GB) | 2005-10-12 | — | — | CN | claimed |
| CN-1662487-A | Amide linker peroxisome proliferator-activated receptor modulators | LILLY CO ELI (US) | 2005-08-31 | — | — | CN | claimed |
| CN-1596106-A | Use of trifluoroacetyl alkyl-substituted phenyl derivatives, phenol derivatives, and benzoyl derivatives in the treatment and/or prophylaxis of obesity and accompanying diseases and/or secondary disea | SOLVAY PHARM GMBH (DE) | 2005-03-16 | — | — | CN | claimed |
| CN-1582279-A | Peroxisome-activated receptor agonists | LILLY CO ELI (US) | 2005-02-16 | — | — | CN | claimed |
| CN-1486320-A | Inhibitors of kruenza protease and other cysteine proteases | ��ķ��ҽ������˾ | 2004-03-31 | — | — | CN | claimed |
| CN-1479728-A | Peroxisome proliferator activated receptor alpha agonists | — | 2004-03-03 | — | — | CN | claimed |