Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 20/20 | 0.79 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4038069 | 0.90 | KIF11 (0.92) | KIF11 | |
| SCHEMBL4038230 | 0.90 | KIF11 (0.79) | KIF11 | |
| SCHEMBL4038208 | 0.89 | KIF11 (0.76) | KIF11 | |
| SCHEMBL3871453 | 0.88 | KIF11 (1.00) | KIF11 | |
| SCHEMBL4037728 | 0.88 | KIF11 (0.75) | KIF11 | |
| SCHEMBL4040590 | 0.88 | KIF11 (0.80) | KIF11 | |
| SCHEMBL4042044 | 0.88 | KIF11 (0.91) | KIF11 | |
| SCHEMBL3873980 | 0.88 | KIF11 (1.00) | KIF11 | |
| SCHEMBL3872670 | 0.88 | KIF11 (1.00) | KIF11 | |
| SCHEMBL4044656 | 0.87 | KIF11 (0.87) | KIF11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7569572-B2 | Pyrazolo[4,3-D]pyrimidines | PFIZER INC (US) | 2009-08-04 | — | — | US | disclosed |
| EP-1620437-B1 | 5,7-DIAMINOPYRAZOLO¬4,3-D PYRIMIDINES USEFUL IN THE TRAETMENT OF HYPERTENSION | PFIZER LTD (GB) | 2009-06-17 | — | — | EP | disclosed |
| EP-1742950-B1 | PYRAZOLO[4,3-D] PYRIMIDINES | PFIZER LTD (GB) | 2008-12-17 | — | — | EP | disclosed |
| US-20080293697-A1 | Pyrazolo[4,3-D]Pyrimidines | BELL ANDREW SIMON | 2008-11-27 | — | — | US | disclosed |
| US-20070270412-A1 | NOVEL PHARMACEUTICALS | PFIZER INC | 2007-11-22 | — | — | US | disclosed |
| US-7262192-B2 | Substituted pyrazolo[4,3-d]pyrimidines and their use as PDE-5 inhibitors | PFIZER INC. (US) | 2007-08-28 | — | — | US | disclosed |
| EP-1742950-A1 | PYRAZOLO[4,3-D] PYRIMIDINES | Pfizer Limited (GB) | 2007-01-17 | — | — | EP | disclosed |
| EP-1620437-A1 | 5,7-DIAMINOPYRAZOLO[4,3-D]PYRIMIDINES USEFUL IN THE TRAETMENT OF HYPERTENSION | Pfizer Limited (GB) | 2006-02-01 | — | — | EP | disclosed |
| WO-2005097799-A1 | PYRAZOLO`4,3-D! PYRIMIDINES | PFIZER LIMITED (GB) | 2005-10-20 | — | — | WO | disclosed |
| US-20050043325-A1 | Novel pharmaceuticals | PFIZER INC | 2005-02-24 | — | — | US | disclosed |
| WO-2004096810-A1 | 5,7-DIAMINOPYRAZOLO`4,3-D!PYRIMIDINES USEFUL IN THE TREATMENT OF HYPERTENSION | PFIZER LIMITED (GB) | 2004-11-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080293697-A1 | Pyrazolo[4,3-D]Pyrimidines | DPYD, TYMS, TYMP | KIF11 1445/4885 |
| US-20050043325-A1 | Novel pharmaceuticals | ABCB11, PCSK9, SLC10A1 | KIF11 2174/4885 |
| US-20070270412-A1 | NOVEL PHARMACEUTICALS | ABCB11, PCSK9, SLC10A1 | KIF11 2174/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.