Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 2/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.39 |
| ▸ | P2RY12 | Q9H244 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | CYP4F2 | P78329 | 4/20 | 0.38 |
| ▸ | CYP4A11 | Q02928 | 4/20 | 0.38 |
| ▸ | APP | P05067 | 1/20 | 0.37 |
| ▸ | ACACB | O00763 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.36 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.35 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.35 |
| ▸ | CACNA1I | Q9P0X4 | 2/20 | 0.34 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.34 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15764197 | 0.83 | PDE3B (0.39) | PDE3BPDE3AP2RY12HTTCYP4F2 | |
| SCHEMBL4034400 | 0.82 | PDE3B (0.39) | PDE3BPDE3AP2RY12HTTCYP4F2 | |
| SCHEMBL4034397 | 0.82 | PDE3B (0.40) | PDE3BPDE3AP2RY12HTTAPP | |
| SCHEMBL28904650 | 0.76 | MAPT (0.51) | PDE3BPDE3AP2RY12HTTAPP | |
| SCHEMBL30026033 | 0.76 | MAPT (0.51) | PDE3BPDE3AP2RY12HTTAPP | |
| SCHEMBL2194940 | 0.76 | NFE2L2 (0.47) | ACACB | |
| SCHEMBL3306252 | 0.75 | PDE3B (0.43) | PDE3BPDE3AP2RY12HTTAPP | |
| SCHEMBL3306255 | 0.75 | PDE3B (0.43) | PDE3BPDE3AP2RY12HTTAPP | |
| SCHEMBL10030181 | 0.75 | L3MBTL1 (0.55) | PDE3BPDE3AP2RY12LMNATP53 | |
| SCHEMBL3300820 | 0.74 | PDE3B (0.42) | PDE3BPDE3AP2RY12HTTCYP4F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2066637-A1 | NOVEL SUBSTITUTED BIPYRIDINE DERIVATIVES AND THEIR USE AS ADENOSINE RECEPTOR LIGANDS | Bayer HealthCare AG (DE) | 2009-06-10 | — | — | EP | disclosed |
| WO-2008028590-A1 | NOVEL SUBSTITUTED BIPYRIDINE DERIVATIVES AND THEIR USE AS ADENOSINE RECEPTOR LIGANDS | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2008-03-13 | — | — | WO | disclosed |