Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.41 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.36 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | RXRA | P19793 | 1/20 | 0.33 |
| ▸ | RXRB | P28702 | 1/20 | 0.33 |
| ▸ | RXRG | P48443 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9099722 | 0.95 | KMT2A (0.48) | KMT2AMEN1CYP4F2CYP4A11ALDH1A1 | |
| SCHEMBL4056563 | 0.76 | POLB (0.43) | KMT2AMEN1ALDH1A1POLBESR1 | |
| SCHEMBL116553 | 0.73 | OPRM1 (0.39) | LMNAPOLBMAOAMAOBOPRM1 | |
| SCHEMBL158414 | 0.73 | CYP4F2 (0.52) | KMT2AMEN1CYP4F2CYP4A11ALDH1A1 | |
| SCHEMBL28450968 | 0.71 | KMT2A (0.38) | KMT2AMEN1CYP4F2CYP4A11ALDH1A1 | |
| SCHEMBL15132784 | 0.71 | KMT2A (0.48) | KMT2AMEN1ALDH1A1LMNAPOLB | |
| SCHEMBL4047527 | 0.70 | MCHR1 (0.49) | — | |
| SCHEMBL9838267 | 0.69 | KMT2A (0.49) | KMT2AMEN1ALDH1A1LMNAPOLB | |
| SCHEMBL9098986 | 0.69 | ALDH1A1 (0.43) | KMT2AMEN1CYP4F2CYP4A11ALDH1A1 | |
| SCHEMBL9100183 | 0.69 | KMT2A (0.46) | KMT2AMEN1ALDH1A1LMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009103478-A1 | PYRIDONE AND PYRIDAZINONE DERIVATIVES AS MCH ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-08-27 | — | — | WO | disclosed |