Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.42 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.42 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | HRH1 | P35367 | 1/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
| ▸ | HTR5A | P47898 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | POLA1 | P09884 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL731400 | 0.91 | KDM1A (0.49) | KDM1ACYP2C19CYP2C9TSHRCYP3A4 | |
| SCHEMBL18793793 | 0.81 | CYP3A4 (0.49) | KDM1ACYP2C19CYP2C9TSHRCYP3A4 | |
| SCHEMBL29337389 | 0.81 | CYP3A4 (0.49) | KDM1ACYP2C19CYP2C9TSHRCYP3A4 | |
| SCHEMBL18793785 | 0.81 | CYP3A4 (0.49) | KDM1ACYP2C19CYP2C9TSHRCYP3A4 | |
| SCHEMBL23976448 | 0.78 | BACE1 (0.39) | KDM1ACYP2C19 | |
| SCHEMBL28970245 | 0.78 | BACE1 (0.39) | KDM1ACYP2C19 | |
| SCHEMBL30060666 | 0.78 | BACE1 (0.39) | KDM1ACYP2C19 | |
| SCHEMBL28970246 | 0.78 | KDM1A (0.44) | KDM1ACYP3A4SLC6A3SLC6A4 | |
| SCHEMBL23977007 | 0.78 | KDM1A (0.44) | KDM1ACYP3A4SLC6A3SLC6A4 | |
| SCHEMBL28970240 | 0.78 | BACE1 (0.39) | KDM1ACYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2010540-B1 | SPIRO-IMIDAZO COMPOUNDS | NOVARTIS AG (CH) | 2012-12-05 | — | — | EP | disclosed |
| US-20090192145-A1 | Spiro-Imidazo Compounds | SPEEDEL EXPERIMENTA AG (CH) | 2009-07-30 | — | — | US | disclosed |
| EP-2010540-A1 | SPIRO-IMIDAZO COMPOUNDS | Speedel Experimenta AG (CH) | 2009-01-07 | — | — | EP | disclosed |
| WO-2007116098-A1 | SPIRO-IMIDAZO COMPOUNDS | SPEEDEL EXPERIMENTA AG (CH) | 2007-10-18 | — | — | WO | disclosed |
| US-5444079-A | Arthropodicidal oxazolines | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1995-08-22 | — | — | US | disclosed |
| EP-0637302-A1 | ARTHROPODICIDAL OXA- AND THIA-ZOLINES | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1995-02-08 | — | — | EP | disclosed |
| WO-1993021165-A1 | ARTHROPODICIDAL OXA- AND THIA-ZOLINES | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1993-10-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090192145-A1 | Spiro-Imidazo Compounds | REN, NR3C2, AGTR1 | KDM1A 3697/4885CYP2C19 89/4885CYP2C9 116/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.