Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.39 |
| ▸ | PFKFB4 | Q16877 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.36 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | RAD52 | P43351 | 1/20 | 0.35 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.35 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4049428 | 0.94 | TP53 (0.38) | GAAALDH1A1MAPTMAPK1HSD17B10 | |
| SCHEMBL4040894 | 0.85 | MAPK1 (0.40) | GAAALDH1A1MAPTMAPK1HSD17B10 | |
| SCHEMBL4049133 | 0.84 | CACNA1B (0.44) | ALDH1A1MAPTMAPK1HSD17B10KDM4E | |
| SCHEMBL4045889 | 0.83 | CACNA1B (0.43) | GAAALDH1A1MAPTL3MBTL1KDM4E | |
| SCHEMBL4044236 | 0.83 | MAOB (0.43) | GAAALDH1A1MAPTMAPK1HSD17B10 | |
| SCHEMBL4103520 | 0.81 | KDM4E (0.39) | GAAALDH1A1MAPTL3MBTL1KDM4E | |
| SCHEMBL4037140 | 0.80 | MAPK1 (0.36) | MAPK1KDM4EKMT2AMEN1TDP1 | |
| SCHEMBL4044883 | 0.79 | CACNA1B (0.43) | GAAALDH1A1MAPTL3MBTL1KDM4E | |
| SCHEMBL5414630 | 0.78 | CACNA1B (0.40) | GAAALDH1A1MAPTL3MBTL1KDM4E | |
| SCHEMBL4047988 | 0.77 | MAPT (0.41) | GAAALDH1A1MAPTMAPK1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1603921-B1 | THIADIBENZOAZULENE DERIVATIVES FOR THE TREATMENT OF INFLAMMATORY DISEASES | GLAXOSMITHKLINE ZAGREB (HR) | 2009-06-17 | — | — | EP | disclosed |
| US-20060069149-A1 | Thiadibenzoazulene derivatives for the treatment of inflammatory diseases | PLIVA-ISTRAZIVACKI INSTITUT D.O.O. (HR) | 2006-03-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060069149-A1 | Thiadibenzoazulene derivatives for the treatment of inflammatory diseases | IL1B, IL1A, TNF | GAA 697/4885ALDH1A1 35/4885MAPT 1841/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.