Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 3/20 | 0.42 |
| ▸ | KIF23 | Q02241 | 1/20 | 0.42 |
| ▸ | GNRHR | P30968 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | PLK1 | P53350 | 2/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | MKNK2 | Q9HBH9 | 4/20 | 0.33 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.33 |
| ▸ | SCD | O00767 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | STK17B | O94768 | 1/20 | 0.32 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.32 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3863849 | 0.92 | KIF11 (0.49) | KIF11KIF23GNRHRGAABRD4 | |
| SCHEMBL4061532 | 0.91 | KIF11 (0.41) | KIF11KIF23GNRHRBRD4PLK1 | |
| SCHEMBL4057634 | 0.88 | KIF11 (0.51) | KIF11KIF23GNRHRGAABRD4 | |
| SCHEMBL4042343 | 0.85 | KIF11 (0.38) | KIF11GNRHRPOLBGAABRD4 | |
| SCHEMBL3871323 | 0.81 | KIF11 (0.49) | KIF11KIF23GAABRD4TLR7 | |
| SCHEMBL4060625 | 0.81 | KIF11 (0.41) | KIF11KIF23GNRHRPOLBBRD4 | |
| SCHEMBL13956802 | 0.78 | KIF11 (0.46) | KIF11GNRHRBRD4DYRK1AALDH1A1 | |
| SCHEMBL3871312 | 0.77 | KIF11 (0.46) | KIF11GNRHRBRD4DYRK1ASCD | |
| SCHEMBL4039832 | 0.77 | KIF11 (0.48) | KIF11KIF23GNRHRGAABRD4 | |
| SCHEMBL4059943 | 0.77 | TSHR (0.39) | KIF11GNRHRPOLBBRD4PLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1601673-B1 | FUSED HETEROCYCLES AND USES THEREOF | ASTRAZENECA AB (SE) | 2009-06-10 | — | — | EP | disclosed |